FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089721343> ?p ?o ?g. }

• W3089721343 endingPage "72" @default.
• W3089721343 startingPage "67" @default.
• W3089721343 abstract "Background: Pergularia tomentosa is a member of the Apocynaceae family found in a wide geographical region including the Gulf region, North Africa and the Middle East. It is known as Fattaka, Ghalqa or Am Lebina in Saudi Arabia, It is used as a remedy for the treatment of skin sores, asthma, and bronchitis. Objective: This study aims to investigate the cytotoxic effects of methanolic extract and Latex (milky secretion) extract. Methods: The stem of Pergularia tomentosa was cut, air dried and soaked for 72 h with methanol repeatedly three times. The crude latex (milk extract) was collected from healthy stem parts of P. tomentosa L by cutting the petiole of leaves, and left to flow where a thick white liquid (Milky) were secreted, collected in amber glass tube and extracted with methanol. Further, the methanolic extract was fractionated by subsequent extraction with various solvents, viz. n-hexane, ethyl acetate and methanol. The cytotoxic effects of Pergularia tomentosa L were evaluated using three cancer cell lines of colon carcinoma (HCT-116), hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7). The cytotoxic effects of Pergularia tomentosa L extracts against HCT-116, HepG2, and MCF-7 were determined by crystal violet staining method. Results: The potency of plant extract to decrease the cell viability of human cancer cells was arranged in descending order as follows: Methanol extract (IC50 = 10.2 μg/ml, 13.6 μg/ml and 29.5μg/ml, respectively). > Milky secretion extract (IC50 = 52.6 μg/ml, 58.6 μg/ml and 120 µg/ml, respectively). Methanolic extract was strong cytotoxic activity against HCT-116 and HepG2 (IC50= 10.2, 13.6 µg/ml, respectively) and moderately activity against MCF-7 (IC50= 29.5 µg/ml). The Milky extract exhibited moderate activity against HCT-116 and HepG2 (IC50= 52.6-58.6 µg/ml, respectively) and weak activity against MCF-7 (120.0 µg/ml). Conclusion: The methanol extract of Pergularia tomentosa L showed higher cytotoxic effect as compared to the Latex (Milky secretion) extract. These extracts can be used as natural antitumor. In Future modern chromatographic separations are needed to get more quantity of metabolites. Further detailed investigation of the isolated metabolites is required to identify the phytoconstituents responsible for antioxidant and cytotoxic effects." @default.
• W3089721343 created "2020-10-08" @default.
• W3089721343 creator A5042532613 @default.
• W3089721343 creator A5045082810 @default.
• W3089721343 creator A5062194117 @default.
• W3089721343 date "2021-02-01" @default.
• W3089721343 modified "2023-09-30" @default.
• W3089721343 title "Evaluation of Cytotoxic Effects of Methanolic Extract of Pergularia tomentosa L Growing Wild in KSA" @default.
• W3089721343 doi "https://doi.org/10.31557/apjcp.2021.22.s1.67" @default.
• W3089721343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33576214" @default.
• W3089721343 hasPublicationYear "2021" @default.
• W3089721343 type Work @default.
• W3089721343 sameAs 3089721343 @default.
• W3089721343 citedByCount "6" @default.
• W3089721343 countsByYear W30897213432022 @default.
• W3089721343 crossrefType "journal-article" @default.
• W3089721343 hasAuthorship W3089721343A5042532613 @default.
• W3089721343 hasAuthorship W3089721343A5045082810 @default.
• W3089721343 hasAuthorship W3089721343A5062194117 @default.
• W3089721343 hasBestOaLocation W30897213431 @default.
• W3089721343 hasConcept C154317977 @default.
• W3089721343 hasConcept C185592680 @default.
• W3089721343 hasConcept C202751555 @default.
• W3089721343 hasConcept C2779858419 @default.
• W3089721343 hasConcept C2780007248 @default.
• W3089721343 hasConcept C43617362 @default.
• W3089721343 hasConcept C55493867 @default.
• W3089721343 hasConcept C556039675 @default.
• W3089721343 hasConcept C59822182 @default.
• W3089721343 hasConcept C71924100 @default.
• W3089721343 hasConcept C86803240 @default.
• W3089721343 hasConceptScore W3089721343C154317977 @default.
• W3089721343 hasConceptScore W3089721343C185592680 @default.
• W3089721343 hasConceptScore W3089721343C202751555 @default.
• W3089721343 hasConceptScore W3089721343C2779858419 @default.
• W3089721343 hasConceptScore W3089721343C2780007248 @default.
• W3089721343 hasConceptScore W3089721343C43617362 @default.
• W3089721343 hasConceptScore W3089721343C55493867 @default.
• W3089721343 hasConceptScore W3089721343C556039675 @default.
• W3089721343 hasConceptScore W3089721343C59822182 @default.
• W3089721343 hasConceptScore W3089721343C71924100 @default.
• W3089721343 hasConceptScore W3089721343C86803240 @default.
• W3089721343 hasIssue "S1" @default.
• W3089721343 hasLocation W30897213431 @default.
• W3089721343 hasOpenAccess W3089721343 @default.
• W3089721343 hasPrimaryLocation W30897213431 @default.
• W3089721343 hasRelatedWork W2027136333 @default.
• W3089721343 hasRelatedWork W2047134548 @default.
• W3089721343 hasRelatedWork W2047220117 @default.
• W3089721343 hasRelatedWork W2061414775 @default.
• W3089721343 hasRelatedWork W2127498153 @default.
• W3089721343 hasRelatedWork W2402229443 @default.
• W3089721343 hasRelatedWork W2981713487 @default.
• W3089721343 hasRelatedWork W3215139134 @default.
• W3089721343 hasRelatedWork W4240757957 @default.
• W3089721343 hasRelatedWork W2188861599 @default.
• W3089721343 hasVolume "22" @default.
• W3089721343 isParatext "false" @default.
• W3089721343 isRetracted "false" @default.
• W3089721343 magId "3089721343" @default.
• W3089721343 workType "article" @default.