Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089722040> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3089722040 abstract "Abstract Hyperlipidemia is on the rise in pediatrics, leading to early coronary artery disease complications. Familial hypercholesterolemia is an important risk factor, with the homozygous subtype being more dangerous, yet less prevalent than the heterozygous subtype. Statins are shown to be an effective treatment in this population. This systematic review will emphasize the safety of such drug class in pediatrics, while taking into consideration the latest cholesterol guideline. Cochrane Library, Clinicaltrials.gov, and PubMed were reviewed systematically in June 2019 and rechecked in November 2019 for the past 5 years with keywords like child, safety, hyperlipidemia, and statins, which resulted in nine randomized clinical trials. In short, statins are shown to be intermediately effective—median decrease of low-density lipoprotein cholesterol was 32% achieving the target of < 160 mg/dL in 67% of patients—in lowering lipid levels yet preventing early complications. They are also considered safely tolerated in most cases, even when taken for extended periods, but still not evidently permissible for children below 8 years old, which was the average age of all participants in the trials. Statins should not be given generally for pediatrics of less than 8 years old, in contrast to what was mentioned in the American Heart Association guideline (0–19 age range), since there is no evidence supporting their safety within this age group." @default.
- W3089722040 created "2020-10-08" @default.
- W3089722040 creator A5003686983 @default.
- W3089722040 creator A5008171756 @default.
- W3089722040 creator A5081165045 @default.
- W3089722040 date "2020-01-01" @default.
- W3089722040 modified "2023-10-18" @default.
- W3089722040 title "Safety of Prescribing Statins in Childhood Dyslipidemia" @default.
- W3089722040 cites W1492727725 @default.
- W3089722040 cites W1599578988 @default.
- W3089722040 cites W1910270001 @default.
- W3089722040 cites W2001550141 @default.
- W3089722040 cites W2011695190 @default.
- W3089722040 cites W2020532844 @default.
- W3089722040 cites W2136466059 @default.
- W3089722040 cites W2138269617 @default.
- W3089722040 cites W2168517524 @default.
- W3089722040 cites W2262354148 @default.
- W3089722040 cites W2417818834 @default.
- W3089722040 cites W2498871569 @default.
- W3089722040 cites W2509346813 @default.
- W3089722040 cites W2512010952 @default.
- W3089722040 cites W2745653865 @default.
- W3089722040 cites W2768720246 @default.
- W3089722040 cites W2789199559 @default.
- W3089722040 cites W2887608209 @default.
- W3089722040 cites W2943105083 @default.
- W3089722040 cites W2947274911 @default.
- W3089722040 cites W2992712814 @default.
- W3089722040 doi "https://doi.org/10.1055/s-0040-1716919" @default.
- W3089722040 hasPublicationYear "2020" @default.
- W3089722040 type Work @default.
- W3089722040 sameAs 3089722040 @default.
- W3089722040 citedByCount "0" @default.
- W3089722040 crossrefType "journal-article" @default.
- W3089722040 hasAuthorship W3089722040A5003686983 @default.
- W3089722040 hasAuthorship W3089722040A5008171756 @default.
- W3089722040 hasAuthorship W3089722040A5081165045 @default.
- W3089722040 hasBestOaLocation W30897220401 @default.
- W3089722040 hasConcept C126322002 @default.
- W3089722040 hasConcept C134018914 @default.
- W3089722040 hasConcept C142724271 @default.
- W3089722040 hasConcept C168563851 @default.
- W3089722040 hasConcept C187212893 @default.
- W3089722040 hasConcept C2776478404 @default.
- W3089722040 hasConcept C2778096610 @default.
- W3089722040 hasConcept C2778163477 @default.
- W3089722040 hasConcept C2779091943 @default.
- W3089722040 hasConcept C2779120738 @default.
- W3089722040 hasConcept C2779134260 @default.
- W3089722040 hasConcept C2780182762 @default.
- W3089722040 hasConcept C2908647359 @default.
- W3089722040 hasConcept C535046627 @default.
- W3089722040 hasConcept C555293320 @default.
- W3089722040 hasConcept C71924100 @default.
- W3089722040 hasConcept C99454951 @default.
- W3089722040 hasConceptScore W3089722040C126322002 @default.
- W3089722040 hasConceptScore W3089722040C134018914 @default.
- W3089722040 hasConceptScore W3089722040C142724271 @default.
- W3089722040 hasConceptScore W3089722040C168563851 @default.
- W3089722040 hasConceptScore W3089722040C187212893 @default.
- W3089722040 hasConceptScore W3089722040C2776478404 @default.
- W3089722040 hasConceptScore W3089722040C2778096610 @default.
- W3089722040 hasConceptScore W3089722040C2778163477 @default.
- W3089722040 hasConceptScore W3089722040C2779091943 @default.
- W3089722040 hasConceptScore W3089722040C2779120738 @default.
- W3089722040 hasConceptScore W3089722040C2779134260 @default.
- W3089722040 hasConceptScore W3089722040C2780182762 @default.
- W3089722040 hasConceptScore W3089722040C2908647359 @default.
- W3089722040 hasConceptScore W3089722040C535046627 @default.
- W3089722040 hasConceptScore W3089722040C555293320 @default.
- W3089722040 hasConceptScore W3089722040C71924100 @default.
- W3089722040 hasConceptScore W3089722040C99454951 @default.
- W3089722040 hasLocation W30897220401 @default.
- W3089722040 hasOpenAccess W3089722040 @default.
- W3089722040 hasPrimaryLocation W30897220401 @default.
- W3089722040 hasRelatedWork W10351664 @default.
- W3089722040 hasRelatedWork W14584704 @default.
- W3089722040 hasRelatedWork W18566451 @default.
- W3089722040 hasRelatedWork W2492162 @default.
- W3089722040 hasRelatedWork W3163895 @default.
- W3089722040 hasRelatedWork W3560767 @default.
- W3089722040 hasRelatedWork W6475906 @default.
- W3089722040 hasRelatedWork W6556809 @default.
- W3089722040 hasRelatedWork W6806859 @default.
- W3089722040 hasRelatedWork W19477119 @default.
- W3089722040 isParatext "false" @default.
- W3089722040 isRetracted "false" @default.
- W3089722040 magId "3089722040" @default.
- W3089722040 workType "article" @default.