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- W3089742054 endingPage "111389" @default.
- W3089742054 startingPage "111389" @default.
- W3089742054 abstract "• Phytochemicals are secondary metabolites of plants which find application in human disease therapy. • Stability and degradation of phytochemicals in the GI tract is a challenge which can be overcome by nano-conjugation. • Various types of organic and inorganic nanocarriers are employed for nanoformulations. • Biomedical applications of phytochemical nanoformulations include use as nanomedicine, antimicrobials and diagnostic agents. In recent times, phytochemicals encapsulated or conjugated with nanocarriers for delivery to the specific sites have gained considerable research interest. Phytochemicals are mostly plant secondary metabolites which reported to be beneficial for human health and in disease theraphy. However, these compound are large size and polar nature of these compounds, make it difficult to cross the blood-brain barrier (BBB), endothelial lining of blood vessels, gastrointestinal tract and mucosa. Moreover, they are enzymatically degraded in the gastrointestinal tract. Therefore, encapsulation or conjugation of these compounds with nanocrriers could be an alternate way to enhance their bioefficacy by influencing their gastrointestinal stability, rate of absorption and dispersion. This review presents an overview of nanocarriers alternatives which improves therapeutic value and avoid toxicity, by releasing bioactive compounds specifically at target tissues with enhanced stability and bioavailability. Future investigations may emphasize on deciphering the structural changes in nanocarriers during digestion and absorption, the difference between in-vitro and in-vivo digestion simulations, and impact of nanocarriers on the metabolism of phytochemicals." @default.
- W3089742054 created "2020-10-08" @default.
- W3089742054 creator A5022296734 @default.
- W3089742054 creator A5058520320 @default.
- W3089742054 creator A5086036949 @default.
- W3089742054 creator A5091332602 @default.
- W3089742054 date "2021-01-01" @default.
- W3089742054 modified "2023-10-09" @default.
- W3089742054 title "Phytochemical delivery through nanocarriers: a review" @default.
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