FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089743560> ?p ?o ?g. }

• W3089743560 abstract "Abstract Motivation Co-expression networks are a powerful gene expression analysis method to study how genes co-express together in clusters with functional coherence that usually resemble specific cell type behaviour for the genes involved. They can be applied to bulk-tissue gene expression profiling and assign function, and usually cell type specificity, to a high percentage of the gene pool used to construct the network. One of the limitations of this method is that each gene is predicted to play a role in a specific set of coherent functions in a single cell type (i.e. at most we get a single <gene, function, cell type> for each gene). We present here GMSCA (Gene Multifunctionality Secondary Co-expression Analysis), a software tool that exploits the co-expression paradigm to increase the number of functions and cell types ascribed to a gene in bulk-tissue co-expression networks. Results We applied GMSCA to 27 co-expression networks derived from bulk-tissue gene expression profiling of a variety of brain tissues. Neurons and glial cells (microglia, astrocytes and oligodendrocytes) were considered the main cell types. Applying this approach, we increase the overall number of predicted triplets <gene, function, cell type> by 46.73%. Moreover, GMSCA predicts that the SNCA gene, traditionally associated to work mainly in neurons, also plays a relevant function in oligodendrocytes. Availability The tool is available at GitHub, https://github.com/drlaguna/GMSCA as open source software. Implementation GSMCA is implemented in R." @default.
• W3089743560 created "2020-10-08" @default.
• W3089743560 creator A5010950235 @default.
• W3089743560 creator A5025988686 @default.
• W3089743560 creator A5028231629 @default.
• W3089743560 creator A5030158904 @default.
• W3089743560 creator A5033311649 @default.
• W3089743560 creator A5041676520 @default.
• W3089743560 creator A5042439287 @default.
• W3089743560 creator A5045734117 @default.
• W3089743560 creator A5059757565 @default.
• W3089743560 creator A5061200075 @default.
• W3089743560 date "2020-10-01" @default.
• W3089743560 modified "2023-10-16" @default.
• W3089743560 title "Modeling multifunctionality of genes with secondary gene co-expression networks in human brain provides novel disease insights" @default.
• W3089743560 cites W1483657409 @default.
• W3089743560 cites W1533942137 @default.
• W3089743560 cites W1580018887 @default.
• W3089743560 cites W1815242288 @default.
• W3089743560 cites W1965778124 @default.
• W3089743560 cites W1966327575 @default.
• W3089743560 cites W1974033269 @default.
• W3089743560 cites W1979283544 @default.
• W3089743560 cites W1985987855 @default.
• W3089743560 cites W2010653277 @default.
• W3089743560 cites W2060981348 @default.
• W3089743560 cites W2076078146 @default.
• W3089743560 cites W2081837126 @default.
• W3089743560 cites W2082907050 @default.
• W3089743560 cites W2091265794 @default.
• W3089743560 cites W2094379190 @default.
• W3089743560 cites W2095565380 @default.
• W3089743560 cites W2119519240 @default.
• W3089743560 cites W2123431154 @default.
• W3089743560 cites W2124954099 @default.
• W3089743560 cites W2135374418 @default.
• W3089743560 cites W2139506875 @default.
• W3089743560 cites W2139511828 @default.
• W3089743560 cites W2150656456 @default.
• W3089743560 cites W2158261276 @default.
• W3089743560 cites W2159767718 @default.
• W3089743560 cites W2191292005 @default.
• W3089743560 cites W2279734831 @default.
• W3089743560 cites W2523620612 @default.
• W3089743560 cites W2577490495 @default.
• W3089743560 cites W2606575226 @default.
• W3089743560 cites W2746479894 @default.
• W3089743560 cites W2768408354 @default.
• W3089743560 cites W2794891507 @default.
• W3089743560 cites W2901332105 @default.
• W3089743560 cites W2902374753 @default.
• W3089743560 cites W2942610007 @default.
• W3089743560 cites W2942678593 @default.
• W3089743560 cites W2949693884 @default.
• W3089743560 cites W2952240309 @default.
• W3089743560 cites W2952898251 @default.
• W3089743560 cites W2953866345 @default.
• W3089743560 cites W2999081734 @default.
• W3089743560 cites W3000010184 @default.
• W3089743560 cites W3019747475 @default.
• W3089743560 cites W3037148986 @default.
• W3089743560 cites W3099404564 @default.
• W3089743560 doi "https://doi.org/10.1101/2020.09.29.317305" @default.
• W3089743560 hasPublicationYear "2020" @default.
• W3089743560 type Work @default.
• W3089743560 sameAs 3089743560 @default.
• W3089743560 citedByCount "0" @default.
• W3089743560 crossrefType "posted-content" @default.
• W3089743560 hasAuthorship W3089743560A5010950235 @default.
• W3089743560 hasAuthorship W3089743560A5025988686 @default.
• W3089743560 hasAuthorship W3089743560A5028231629 @default.
• W3089743560 hasAuthorship W3089743560A5030158904 @default.
• W3089743560 hasAuthorship W3089743560A5033311649 @default.
• W3089743560 hasAuthorship W3089743560A5041676520 @default.
• W3089743560 hasAuthorship W3089743560A5042439287 @default.
• W3089743560 hasAuthorship W3089743560A5045734117 @default.
• W3089743560 hasAuthorship W3089743560A5059757565 @default.
• W3089743560 hasAuthorship W3089743560A5061200075 @default.
• W3089743560 hasBestOaLocation W30897435601 @default.
• W3089743560 hasConcept C104317684 @default.
• W3089743560 hasConcept C14036430 @default.
• W3089743560 hasConcept C1491633281 @default.
• W3089743560 hasConcept C150194340 @default.
• W3089743560 hasConcept C165864922 @default.
• W3089743560 hasConcept C18431079 @default.
• W3089743560 hasConcept C189014844 @default.
• W3089743560 hasConcept C54355233 @default.
• W3089743560 hasConcept C67339327 @default.
• W3089743560 hasConcept C70721500 @default.
• W3089743560 hasConcept C86803240 @default.
• W3089743560 hasConceptScore W3089743560C104317684 @default.
• W3089743560 hasConceptScore W3089743560C14036430 @default.
• W3089743560 hasConceptScore W3089743560C1491633281 @default.
• W3089743560 hasConceptScore W3089743560C150194340 @default.
• W3089743560 hasConceptScore W3089743560C165864922 @default.
• W3089743560 hasConceptScore W3089743560C18431079 @default.
• W3089743560 hasConceptScore W3089743560C189014844 @default.
• W3089743560 hasConceptScore W3089743560C54355233 @default.
• W3089743560 hasConceptScore W3089743560C67339327 @default.
• W3089743560 hasConceptScore W3089743560C70721500 @default.

• next