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- W3089751192 endingPage "122" @default.
- W3089751192 startingPage "122" @default.
- W3089751192 abstract "Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While there are many aspects to consider in the design of biomaterials, mechanical properties can be of particular importance in this dynamically remodeling tissue. This review focuses on one specific processing method, electrospinning, that is employed to generate materials with a fibrous microstructure that can be combined with material properties to achieve the desired mechanical behavior. Current methods used to fabricate mechanically relevant micro-/nanofibrous scaffolds, in vivo studies using these scaffolds as therapeutics, and common techniques to characterize the mechanical properties of the scaffolds are covered. We also discuss the discrepancies in the reported elastic modulus for physiological and pathological myocardium in the literature, as well as the emerging area of in vitro mechanobiology studies to investigate the mechanical regulation in cardiac tissue engineering. Lastly, future perspectives and recommendations are offered in order to enhance the understanding of cardiac mechanobiology and foster therapeutic development in myocardial regenerative medicine." @default.
- W3089751192 created "2020-10-08" @default.
- W3089751192 creator A5037012845 @default.
- W3089751192 creator A5058549894 @default.
- W3089751192 creator A5066982563 @default.
- W3089751192 date "2020-10-03" @default.
- W3089751192 modified "2023-09-26" @default.
- W3089751192 title "Mechanical Considerations of Electrospun Scaffolds for Myocardial Tissue and Regenerative Engineering" @default.
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