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- W3089762215 abstract "Over the past few decades, the development of bacterial resistance of antibiotics and dose-related toxicity of modern aggressive antibiotics has attracted attention to the dire need of new antibiotic discovery, which is efficient, cost-effective, and biocompatible. The ancient Indian medicinal system (Ayurveda) provided concepts of plant-based pharmacotherapy to treat infectious diseases. Medicinal plant parts contain numerous types of nutraceutical phytochemicals like flavonoids, phenols, thiosulfinate, quinones, alkaloids, terpenes, etc., which deliver significant antimicrobial properties and are known to be effective, edible, and nontoxic drugs. Their mode of action includes DNA inhibition, enzyme inactivation, cell wall and membrane damage, protein misfolding, denaturation, etc. of microorganisms. Several research works successfully demonstrated that these extracts are very effective against a wide range of pathogens and multidrug resistant (MDR) bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA), uropathogens, Klebsiella, Escherichia, etc. However, low extraction yield and unstable nature of phytochemicals pose major constraints in their commercial utilization. Micellization using biocompatible surfactants can be employed for enhanced drug delivery and stability. Naturally derived plant compounds can provide useful and low-cost source of antimicrobials to mitigate the challenges of drug discovery process required for antimicrobial chemotherapy." @default.
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- W3089762215 date "2020-09-30" @default.
- W3089762215 modified "2023-09-26" @default.
- W3089762215 title "Development of Micellized Antimicrobial Thiosulfinate: A Contemporary Way of Drug Stability Enhancement" @default.
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- W3089762215 doi "https://doi.org/10.1007/978-981-15-7409-2_8" @default.
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