FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089763150> ?p ?o ?g. }

• W3089763150 endingPage "3213" @default.
• W3089763150 startingPage "3181" @default.
• W3089763150 abstract "Abstract The complexity of the human brain poses a substantial challenge for the development of models of the CNS. Current animal models lack many essential human characteristics (in addition to raising operational challenges and ethical concerns), and conventional in vitro models, in turn, are limited in their capacity to provide information regarding many functional and systemic responses. Indeed, these challenges may underlie the notoriously low success rates of CNS drug development efforts. During the past 5 years, there has been a leap in the complexity and functionality of in vitro systems of the CNS, which have the potential to overcome many of the limitations of traditional model systems. The availability of human-derived induced pluripotent stem cell technology has further increased the translational potential of these systems. Yet, the adoption of state-of-the-art in vitro platforms within the CNS research community is limited. This may be attributable to the high costs or the immaturity of the systems. Nevertheless, the costs of fabrication have decreased, and there are tremendous ongoing efforts to improve the quality of cell differentiation. Herein, we aim to raise awareness of the capabilities and accessibility of advanced in vitro CNS technologies. We provide an overview of some of the main recent developments (since 2015) in in vitro CNS models. In particular, we focus on engineered in vitro models based on cell culture systems combined with microfluidic platforms (e.g. ‘organ-on-a-chip’ systems). We delve into the fundamental principles underlying these systems and review several applications of these platforms for the study of the CNS in health and disease. Our discussion further addresses the challenges that hinder the implementation of advanced in vitro platforms in personalized medicine or in large-scale industrial settings, and outlines the existing differentiation protocols and industrial cell sources. We conclude by providing practical guidelines for laboratories that are considering adopting organ-on-a-chip technologies." @default.
• W3089763150 created "2020-10-08" @default.
• W3089763150 creator A5022020115 @default.
• W3089763150 creator A5027543861 @default.
• W3089763150 creator A5056536823 @default.
• W3089763150 creator A5071769240 @default.
• W3089763150 creator A5078885120 @default.
• W3089763150 creator A5090573937 @default.
• W3089763150 date "2020-10-06" @default.
• W3089763150 modified "2023-10-05" @default.
• W3089763150 title "Recent progress in translational engineered<i>in vitro</i>models of the central nervous system" @default.
• W3089763150 cites W1112818150 @default.
• W3089763150 cites W1465270826 @default.
• W3089763150 cites W1552543129 @default.
• W3089763150 cites W1577821076 @default.
• W3089763150 cites W1614955264 @default.
• W3089763150 cites W1630758895 @default.
• W3089763150 cites W1646206347 @default.
• W3089763150 cites W1718839160 @default.
• W3089763150 cites W1768523798 @default.
• W3089763150 cites W1772043749 @default.
• W3089763150 cites W1843099843 @default.
• W3089763150 cites W1847104216 @default.
• W3089763150 cites W1848527143 @default.
• W3089763150 cites W1862832045 @default.
• W3089763150 cites W1891667186 @default.
• W3089763150 cites W1895213472 @default.
• W3089763150 cites W1947402635 @default.
• W3089763150 cites W1963637177 @default.
• W3089763150 cites W1963886170 @default.
• W3089763150 cites W1964544761 @default.
• W3089763150 cites W1966123661 @default.
• W3089763150 cites W1966238900 @default.
• W3089763150 cites W1966959914 @default.
• W3089763150 cites W1970206755 @default.
• W3089763150 cites W1973001664 @default.
• W3089763150 cites W1973626590 @default.
• W3089763150 cites W1973651527 @default.
• W3089763150 cites W1973814657 @default.
• W3089763150 cites W1974362648 @default.
• W3089763150 cites W1974604937 @default.
• W3089763150 cites W1974815300 @default.
• W3089763150 cites W1975219368 @default.
• W3089763150 cites W1978208782 @default.
• W3089763150 cites W1979665070 @default.
• W3089763150 cites W1979883589 @default.
• W3089763150 cites W1983300261 @default.
• W3089763150 cites W1983668830 @default.
• W3089763150 cites W1985265644 @default.
• W3089763150 cites W1985958520 @default.
• W3089763150 cites W1987085702 @default.
• W3089763150 cites W1988568961 @default.
• W3089763150 cites W1988676688 @default.
• W3089763150 cites W1991552355 @default.
• W3089763150 cites W1994610707 @default.
• W3089763150 cites W1994812037 @default.
• W3089763150 cites W1995139987 @default.
• W3089763150 cites W1996940538 @default.
• W3089763150 cites W1996950868 @default.
• W3089763150 cites W2000005040 @default.
• W3089763150 cites W2001315558 @default.
• W3089763150 cites W2001726213 @default.
• W3089763150 cites W2002552106 @default.
• W3089763150 cites W2004229492 @default.
• W3089763150 cites W2004260427 @default.
• W3089763150 cites W2004943408 @default.
• W3089763150 cites W2006628284 @default.
• W3089763150 cites W2007911155 @default.
• W3089763150 cites W2008737907 @default.
• W3089763150 cites W2010527387 @default.
• W3089763150 cites W2011876206 @default.
• W3089763150 cites W2013520568 @default.
• W3089763150 cites W2014084405 @default.
• W3089763150 cites W2014107797 @default.
• W3089763150 cites W2015541518 @default.
• W3089763150 cites W2016526951 @default.
• W3089763150 cites W2016589918 @default.
• W3089763150 cites W2017072488 @default.
• W3089763150 cites W2018286352 @default.
• W3089763150 cites W2018585985 @default.
• W3089763150 cites W2018619633 @default.
• W3089763150 cites W2024419084 @default.
• W3089763150 cites W2027060519 @default.
• W3089763150 cites W2028265367 @default.
• W3089763150 cites W2028376002 @default.
• W3089763150 cites W2028936244 @default.
• W3089763150 cites W2029162014 @default.
• W3089763150 cites W2029610231 @default.
• W3089763150 cites W2030338281 @default.
• W3089763150 cites W2030450624 @default.
• W3089763150 cites W2033246037 @default.
• W3089763150 cites W2035831762 @default.
• W3089763150 cites W2036564583 @default.
• W3089763150 cites W2039182173 @default.
• W3089763150 cites W2039767070 @default.
• W3089763150 cites W2041473955 @default.
• W3089763150 cites W2041848964 @default.
• W3089763150 cites W2042883482 @default.

• next