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- W3089777763 endingPage "19" @default.
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- W3089777763 abstract "The polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene (DMBA, D) administered per os to wild-type female mice bearing slow-release medroxyprogesterone (MPA, M) pellets s.c. drives the formation of mammary carcinomas that recapitulate numerous immunobiological features of human luminal B breast cancer. In particular, M/D-driven mammary carcinomas established in immunocompetent C57BL/6 female mice (1) express hormone receptors, (2) emerge by evading natural immunosurveillance and hence display a scarce immune infiltrate largely polarized toward immunosuppression, (3) exhibit exquisite sensitivity to CDK4/CDK6 inhibitors, and (4) are largely resistant to immunotherapy with immune checkpoint blockers targeting PD-1. Thus, M/D-driven mammary carcinomas evolving in immunocompetent female mice stand out as a privileged preclinical platform for the study of luminal B breast cancer. Here, we provide a detailed protocol for the establishment of M/D-driven mammary carcinomas in wild-type C57BL/6 female mice. This protocol can be easily adapted to generate M/D-driven mammary carcinomas in female mice with most genetic backgrounds (including genetically-engineered mice)." @default.
- W3089777763 created "2020-10-08" @default.
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- W3089777763 date "2021-01-01" @default.
- W3089777763 modified "2023-10-11" @default.
- W3089777763 title "MPA/DMBA-driven mammary carcinomas" @default.
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- W3089777763 doi "https://doi.org/10.1016/bs.mcb.2020.08.003" @default.
- W3089777763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33785159" @default.
- W3089777763 hasPublicationYear "2021" @default.
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