FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089783943> ?p ?o ?g. }

• W3089783943 endingPage "108963" @default.
• W3089783943 startingPage "108963" @default.
• W3089783943 abstract "Tissue microarrays (TMAs), where each block (and thus section) contains multiple tissue cores from multiple blocks potentially allow more efficient use of tissue, reagents and time in neuropathology. The relationship between data from TMA cores and whole sections was investigated using ‘virtual’ TMA cores. This involved quantitative assessments of microglial pathology in white matter lesions and motor neuron disease, alongside qualitative TDP-43 inclusion status in motor neuron disease cases. Following this, a protocol was developed for TMA construction. For microglial pathology we found good concordance between virtual cores and whole sections for volume density using one 1.75 mm core (equivalent to a 2 mm core after accounting for peripheral tissue loss). More sophisticated microglial cell size and measures required two cores. Qualitative results of pTDP-43 pathology showed use of one 1.75 mm core gave a 100 % sensitivity and specificity within grey matter, and 88.3 % sensitivity and 100 % specificity within white matter. A method of producing the TMAs was suitable for immunohistochemistry both manually and by autostainer, with the minimal core loss from the microscope slide. TMAs have been used infrequently in post mortem neuropathology research. However, we believe TMAs give comparable tissue assessment results and can be constructed, sectioned and stained with relative ease. We found TMAs could be used to assess both quantitative (microglial pathology) and qualitative pathology (TDP-43 proteinopathy) with greatly reduced quantities of tissue, time and reagents. These could be used for further work to improve data acquisition efficiency." @default.
• W3089783943 created "2020-10-08" @default.
• W3089783943 creator A5003559875 @default.
• W3089783943 creator A5025748762 @default.
• W3089783943 creator A5035247509 @default.
• W3089783943 creator A5049192404 @default.
• W3089783943 creator A5057296812 @default.
• W3089783943 creator A5078441502 @default.
• W3089783943 creator A5080381954 @default.
• W3089783943 creator A5080879544 @default.
• W3089783943 date "2021-01-01" @default.
• W3089783943 modified "2023-09-27" @default.
• W3089783943 title "Tissue microarray (TMA) use in post mortem neuropathology" @default.
• W3089783943 cites W1521835682 @default.
• W3089783943 cites W1839080396 @default.
• W3089783943 cites W1910374374 @default.
• W3089783943 cites W1967062507 @default.
• W3089783943 cites W1973783921 @default.
• W3089783943 cites W1976457544 @default.
• W3089783943 cites W1991044466 @default.
• W3089783943 cites W1993970782 @default.
• W3089783943 cites W1998412423 @default.
• W3089783943 cites W2003618511 @default.
• W3089783943 cites W2031964319 @default.
• W3089783943 cites W2039220230 @default.
• W3089783943 cites W2039762214 @default.
• W3089783943 cites W2052434974 @default.
• W3089783943 cites W2066828509 @default.
• W3089783943 cites W2069893872 @default.
• W3089783943 cites W2076535829 @default.
• W3089783943 cites W2087810003 @default.
• W3089783943 cites W2089435027 @default.
• W3089783943 cites W2100809123 @default.
• W3089783943 cites W2108435419 @default.
• W3089783943 cites W2109598200 @default.
• W3089783943 cites W2120693009 @default.
• W3089783943 cites W2147596506 @default.
• W3089783943 cites W2158705875 @default.
• W3089783943 cites W2159759971 @default.
• W3089783943 cites W2160290970 @default.
• W3089783943 cites W2162758137 @default.
• W3089783943 cites W2181624373 @default.
• W3089783943 cites W2322893324 @default.
• W3089783943 cites W2592969263 @default.
• W3089783943 cites W2606791048 @default.
• W3089783943 cites W2624000744 @default.
• W3089783943 cites W2750760521 @default.
• W3089783943 cites W2809088789 @default.
• W3089783943 cites W2967050694 @default.
• W3089783943 doi "https://doi.org/10.1016/j.jneumeth.2020.108963" @default.
• W3089783943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33007345" @default.
• W3089783943 hasPublicationYear "2021" @default.
• W3089783943 type Work @default.
• W3089783943 sameAs 3089783943 @default.
• W3089783943 citedByCount "2" @default.
• W3089783943 countsByYear W30897839432022 @default.
• W3089783943 countsByYear W30897839432023 @default.
• W3089783943 crossrefType "journal-article" @default.
• W3089783943 hasAuthorship W3089783943A5003559875 @default.
• W3089783943 hasAuthorship W3089783943A5025748762 @default.
• W3089783943 hasAuthorship W3089783943A5035247509 @default.
• W3089783943 hasAuthorship W3089783943A5049192404 @default.
• W3089783943 hasAuthorship W3089783943A5057296812 @default.
• W3089783943 hasAuthorship W3089783943A5078441502 @default.
• W3089783943 hasAuthorship W3089783943A5080381954 @default.
• W3089783943 hasAuthorship W3089783943A5080879544 @default.
• W3089783943 hasBestOaLocation W30897839432 @default.
• W3089783943 hasConcept C105702510 @default.
• W3089783943 hasConcept C126838900 @default.
• W3089783943 hasConcept C142724271 @default.
• W3089783943 hasConcept C143409427 @default.
• W3089783943 hasConcept C160798450 @default.
• W3089783943 hasConcept C193270364 @default.
• W3089783943 hasConcept C204232928 @default.
• W3089783943 hasConcept C2778013878 @default.
• W3089783943 hasConcept C2779134260 @default.
• W3089783943 hasConcept C2780130745 @default.
• W3089783943 hasConcept C2781192897 @default.
• W3089783943 hasConcept C2986936838 @default.
• W3089783943 hasConcept C60644358 @default.
• W3089783943 hasConcept C71924100 @default.
• W3089783943 hasConcept C86803240 @default.
• W3089783943 hasConceptScore W3089783943C105702510 @default.
• W3089783943 hasConceptScore W3089783943C126838900 @default.
• W3089783943 hasConceptScore W3089783943C142724271 @default.
• W3089783943 hasConceptScore W3089783943C143409427 @default.
• W3089783943 hasConceptScore W3089783943C160798450 @default.
• W3089783943 hasConceptScore W3089783943C193270364 @default.
• W3089783943 hasConceptScore W3089783943C204232928 @default.
• W3089783943 hasConceptScore W3089783943C2778013878 @default.
• W3089783943 hasConceptScore W3089783943C2779134260 @default.
• W3089783943 hasConceptScore W3089783943C2780130745 @default.
• W3089783943 hasConceptScore W3089783943C2781192897 @default.
• W3089783943 hasConceptScore W3089783943C2986936838 @default.
• W3089783943 hasConceptScore W3089783943C60644358 @default.
• W3089783943 hasConceptScore W3089783943C71924100 @default.
• W3089783943 hasConceptScore W3089783943C86803240 @default.
• W3089783943 hasFunder F4320320229 @default.

• next