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- W3089789683 abstract "More people are surviving longer with cancer. Whilst this can be partially attributed to advances in early detection of cancers, there is little doubt that the improvement in survival statistics is also due to the expansion in the spectrum of treatments available for efficacious treatment. Transformative amongst those are immunotherapies, which have proven effective agents for treating immunogenic forms of cancer, although immunologically “cold” tumour types remain refractive. Oncolytic viruses, such as those based on adenovirus, have great potential as anti-cancer agents and have seen a resurgence of interest in recent years. Amongst their many advantages is their ability to induce immunogenic cell death (ICD) of infected tumour cells, thus providing the alluring potential to synergise with immunotherapies by turning immunologically “cold” tumours “hot”. Additionally, enhanced immune mediated cell killing can be promoted through the local overexpression of immunological transgenes, encoded from within the engineered viral genome. To achieve this full potential requires the development of refined, tumour selective “precision virotherapies” that are extensively engineered to prevent off-target up take via native routes of infection and targeted to infect and replicate uniquely within malignantly transformed cells. Here, we review the latest advances towards this holy grail within the adenoviral field." @default.
- W3089789683 created "2020-10-08" @default.
- W3089789683 creator A5036797306 @default.
- W3089789683 creator A5074127520 @default.
- W3089789683 creator A5077500117 @default.
- W3089789683 date "2020-11-11" @default.
- W3089789683 modified "2023-10-14" @default.
- W3089789683 title "Hitting the Target but Missing the Point: Recent Progress towards Adenovirus-Based Precision Virotherapies" @default.
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