FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089806001> ?p ?o ?g. }

• W3089806001 abstract "ABSTRACT Extracellular vesicles (EVs) have been described as mediators of microorganism survival and interaction with the host. In Candida albicans , a relevant commensal fungal pathogen, the dimorphic transition is an important virulence trait in candidiasis. We have analyzed EVs secreted by yeast (YEVs) or hyphal cells (HEVs) from C. albicans , finding interesting differences in both size distribution and protein loading. In general, HEVs were smaller and carried a much more diverse protein cargo than YEVs, including most of the proteins identified in YEVs, which were mainly cell surface proteins. Virulence factors such as phospholipases, aspartic proteases (Saps), adhesins and invasins, and the precursor protein of candidalysin toxin Ece1p were also detected. HEVs were also enriched in proteasomal and ribosomal proteins, and in enzymes from amino acid biosynthetic pathways, all involved in protein metabolism, as well as proteins related to intracellular protein transport and components of the ESCRT pathway related to exosome biogenesis. Both types of EV presented immune reactivity with human sera from patients suffering invasive candidiasis. In our conditions, only HEVs could elicit the release of TNFα by activated macrophages. This first analysis of C. albicans HEVs shows their relevance to pathogenesis and possible new diagnostics or treatments." @default.
• W3089806001 created "2020-10-08" @default.
• W3089806001 creator A5008035992 @default.
• W3089806001 creator A5009471545 @default.
• W3089806001 creator A5027104453 @default.
• W3089806001 creator A5063713420 @default.
• W3089806001 creator A5072345758 @default.
• W3089806001 creator A5072578905 @default.
• W3089806001 creator A5080672941 @default.
• W3089806001 date "2020-10-05" @default.
• W3089806001 modified "2023-10-13" @default.
• W3089806001 title "Small extracellular vesicles secreted by Candida albicans hyphae have highly diverse protein cargoes that include virulence factors and stimulate macrophages" @default.
• W3089806001 cites W1535528935 @default.
• W3089806001 cites W1839486704 @default.
• W3089806001 cites W1915536483 @default.
• W3089806001 cites W1937936144 @default.
• W3089806001 cites W1970770879 @default.
• W3089806001 cites W1978415706 @default.
• W3089806001 cites W2000633818 @default.
• W3089806001 cites W2003199362 @default.
• W3089806001 cites W2003564377 @default.
• W3089806001 cites W2011780036 @default.
• W3089806001 cites W2022948162 @default.
• W3089806001 cites W2027249101 @default.
• W3089806001 cites W2031695033 @default.
• W3089806001 cites W2032984007 @default.
• W3089806001 cites W2034674073 @default.
• W3089806001 cites W2047847342 @default.
• W3089806001 cites W2060721894 @default.
• W3089806001 cites W2073681519 @default.
• W3089806001 cites W2079553804 @default.
• W3089806001 cites W2081937775 @default.
• W3089806001 cites W2096343569 @default.
• W3089806001 cites W2098259366 @default.
• W3089806001 cites W2105706954 @default.
• W3089806001 cites W2106860332 @default.
• W3089806001 cites W2111357564 @default.
• W3089806001 cites W2114164442 @default.
• W3089806001 cites W2114593853 @default.
• W3089806001 cites W2121354606 @default.
• W3089806001 cites W2124008198 @default.
• W3089806001 cites W2125636530 @default.
• W3089806001 cites W2127891436 @default.
• W3089806001 cites W2129629034 @default.
• W3089806001 cites W2166987747 @default.
• W3089806001 cites W2167246272 @default.
• W3089806001 cites W2170132701 @default.
• W3089806001 cites W2221865045 @default.
• W3089806001 cites W2238481953 @default.
• W3089806001 cites W2257123939 @default.
• W3089806001 cites W2259481044 @default.
• W3089806001 cites W2291984511 @default.
• W3089806001 cites W2329943654 @default.
• W3089806001 cites W2337785792 @default.
• W3089806001 cites W2462178624 @default.
• W3089806001 cites W2565271826 @default.
• W3089806001 cites W2616928662 @default.
• W3089806001 cites W2773559364 @default.
• W3089806001 cites W2784576924 @default.
• W3089806001 cites W2802975471 @default.
• W3089806001 cites W2894968361 @default.
• W3089806001 cites W2896513955 @default.
• W3089806001 cites W2947196533 @default.
• W3089806001 cites W2956009662 @default.
• W3089806001 cites W2967376136 @default.
• W3089806001 cites W2980061134 @default.
• W3089806001 cites W2989284650 @default.
• W3089806001 cites W3016732475 @default.
• W3089806001 cites W3017376547 @default.
• W3089806001 cites W4211178015 @default.
• W3089806001 cites W4294216483 @default.
• W3089806001 cites W632468597 @default.
• W3089806001 doi "https://doi.org/10.1101/2020.10.02.323774" @default.
• W3089806001 hasPublicationYear "2020" @default.
• W3089806001 type Work @default.
• W3089806001 sameAs 3089806001 @default.
• W3089806001 citedByCount "4" @default.
• W3089806001 countsByYear W30898060012021 @default.
• W3089806001 countsByYear W30898060012023 @default.
• W3089806001 crossrefType "posted-content" @default.
• W3089806001 hasAuthorship W3089806001A5008035992 @default.
• W3089806001 hasAuthorship W3089806001A5009471545 @default.
• W3089806001 hasAuthorship W3089806001A5027104453 @default.
• W3089806001 hasAuthorship W3089806001A5063713420 @default.
• W3089806001 hasAuthorship W3089806001A5072345758 @default.
• W3089806001 hasAuthorship W3089806001A5072578905 @default.
• W3089806001 hasAuthorship W3089806001A5080672941 @default.
• W3089806001 hasBestOaLocation W30898060011 @default.
• W3089806001 hasConcept C102747710 @default.
• W3089806001 hasConcept C104317684 @default.
• W3089806001 hasConcept C143876685 @default.
• W3089806001 hasConcept C145081991 @default.
• W3089806001 hasConcept C181199279 @default.
• W3089806001 hasConcept C182220744 @default.
• W3089806001 hasConcept C2777576037 @default.
• W3089806001 hasConcept C2779222958 @default.
• W3089806001 hasConcept C2780917455 @default.
• W3089806001 hasConcept C2781090273 @default.
• W3089806001 hasConcept C28406088 @default.
• W3089806001 hasConcept C2910135453 @default.

• next