Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089837269> ?p ?o ?g. }
- W3089837269 endingPage "105226" @default.
- W3089837269 startingPage "105226" @default.
- W3089837269 abstract "• Blood-central nervous system (CNS) barriers are impaired in several disorders. • All neurovascular elements of these barriers can participate in their disruption. • Dysfunction of regulatory systems contributes to barrier breakdown. • Different endogenous or exogenous compounds improve barrier integrity. • Multiple pathways may be modulated to protect or repair blood-CNS barriers. Central nervous system (CNS) drug development faces significant difficulties that translate into high rates of failure and lack of innovation. The pathophysiology of neurological and psychiatric disorders often results in the breakdown of blood-CNS barriers, disturbing the CNS microenvironment and worsening disease progression. Therefore, restoring the integrity of blood-CNS barriers may have a beneficial influence in several CNS disorders and improve treatment outcomes. In this review, pathways that may be modulated to protect blood-CNS barriers from neuroinflammatory and oxidative insults are featured. First, the participation of the brain endothelium and glial cells in disruption processes is discussed. Then, the relevance of regulatory systems is analysed, specifically the hypothalamic-pituitary axis, the renin-angiotensin system, sleep and circadian rhythms, and glutamate neurotransmission. Lastly, compounds of endogenous and exogenous origin that are known to mediate the repair of blood-CNS barriers are presented. We believe that enhancing the protection of blood-CNS barriers is a promising therapeutic strategy to pursue in the future." @default.
- W3089837269 created "2020-10-08" @default.
- W3089837269 creator A5000923074 @default.
- W3089837269 creator A5005211993 @default.
- W3089837269 creator A5007472451 @default.
- W3089837269 creator A5019069584 @default.
- W3089837269 date "2020-12-01" @default.
- W3089837269 modified "2023-10-12" @default.
- W3089837269 title "Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders" @default.
- W3089837269 cites W1501414201 @default.
- W3089837269 cites W1532854928 @default.
- W3089837269 cites W1549213315 @default.
- W3089837269 cites W1550399013 @default.
- W3089837269 cites W1560983797 @default.
- W3089837269 cites W1589304766 @default.
- W3089837269 cites W1772460577 @default.
- W3089837269 cites W1793323596 @default.
- W3089837269 cites W1891863012 @default.
- W3089837269 cites W1904090568 @default.
- W3089837269 cites W1955696365 @default.
- W3089837269 cites W1964021320 @default.
- W3089837269 cites W1966698297 @default.
- W3089837269 cites W1968155219 @default.
- W3089837269 cites W1968758728 @default.
- W3089837269 cites W1968940781 @default.
- W3089837269 cites W1969619562 @default.
- W3089837269 cites W1969909530 @default.
- W3089837269 cites W1972723234 @default.
- W3089837269 cites W1973418567 @default.
- W3089837269 cites W1973763077 @default.
- W3089837269 cites W1981307611 @default.
- W3089837269 cites W1985422853 @default.
- W3089837269 cites W1985474890 @default.
- W3089837269 cites W1987037769 @default.
- W3089837269 cites W1988157043 @default.
- W3089837269 cites W1988966858 @default.
- W3089837269 cites W1989034945 @default.
- W3089837269 cites W1989591252 @default.
- W3089837269 cites W1990985572 @default.
- W3089837269 cites W1990996033 @default.
- W3089837269 cites W1993261308 @default.
- W3089837269 cites W1993429855 @default.
- W3089837269 cites W1993894887 @default.
- W3089837269 cites W1998127571 @default.
- W3089837269 cites W1999867225 @default.
- W3089837269 cites W2000087476 @default.
- W3089837269 cites W2003716616 @default.
- W3089837269 cites W2007465397 @default.
- W3089837269 cites W2009574709 @default.
- W3089837269 cites W2009736225 @default.
- W3089837269 cites W2010045296 @default.
- W3089837269 cites W2010444608 @default.
- W3089837269 cites W2011643486 @default.
- W3089837269 cites W2012108027 @default.
- W3089837269 cites W2013499417 @default.
- W3089837269 cites W2014941190 @default.
- W3089837269 cites W2015525302 @default.
- W3089837269 cites W2015541518 @default.
- W3089837269 cites W2019780808 @default.
- W3089837269 cites W2020018765 @default.
- W3089837269 cites W2022120753 @default.
- W3089837269 cites W2024927304 @default.
- W3089837269 cites W2025806954 @default.
- W3089837269 cites W2031213243 @default.
- W3089837269 cites W2031762899 @default.
- W3089837269 cites W2033142272 @default.
- W3089837269 cites W2034135618 @default.
- W3089837269 cites W2036056534 @default.
- W3089837269 cites W2036362108 @default.
- W3089837269 cites W2037190190 @default.
- W3089837269 cites W2037230855 @default.
- W3089837269 cites W2037426713 @default.
- W3089837269 cites W2037943855 @default.
- W3089837269 cites W2039857463 @default.
- W3089837269 cites W2045683532 @default.
- W3089837269 cites W2046158061 @default.
- W3089837269 cites W2046529212 @default.
- W3089837269 cites W2047455712 @default.
- W3089837269 cites W2048085214 @default.
- W3089837269 cites W2048371307 @default.
- W3089837269 cites W2050014158 @default.
- W3089837269 cites W2052779376 @default.
- W3089837269 cites W2052874642 @default.
- W3089837269 cites W2053802535 @default.
- W3089837269 cites W2053929939 @default.
- W3089837269 cites W2055137108 @default.
- W3089837269 cites W2055467683 @default.
- W3089837269 cites W2056752509 @default.
- W3089837269 cites W2056856515 @default.
- W3089837269 cites W2058780134 @default.
- W3089837269 cites W2060188196 @default.
- W3089837269 cites W2060279158 @default.
- W3089837269 cites W2065350174 @default.
- W3089837269 cites W2067450395 @default.
- W3089837269 cites W2071768383 @default.
- W3089837269 cites W2075069825 @default.
- W3089837269 cites W2075757880 @default.
- W3089837269 cites W2079096922 @default.