Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089839475> ?p ?o ?g. }
- W3089839475 abstract "Abstract Anthroponotic cutaneous leishmaniasis (CL) caused by Leishmania tropica ( L. tropica ) represents a public health challenge in several resource poor settings. We herein employed a systems analysis approach to study molecular signatures of CL caused by L. tropica in the skin lesions of ulcerative CL (UCL) and non-ulcerative CL (NUCL) patients. Results from RNA-seq analysis determined shared and unique functional transcriptional pathways in the lesions of the UCL and NUCL patients. Several transcriptional pathways involved in inflammatory response were positively enriched in the CL lesions. A multiplexed inflammatory protein analysis showed differential profiles of inflammatory cytokines and chemokines in the UCL and NUCL lesions. Transcriptional pathways for Fcγ receptor dependent phagocytosis were among shared enriched pathways. Using L. tropica specific antibody (Ab)-mediated phagocytosis assays, we could substantiate Ab-dependent cellular phagocytosis (ADCP) and Ab-dependent neutrophil phagocytosis (ADNP) activities in the lesions of the UCL and NUCL patients, which correlated with L. tropica specific IgG Abs. Interestingly, a negative correlation was observed between parasite load and L. tropica specific IgG/ADCP/ADNP in the skin lesions of CL patients. These results enhance our understanding of human skin response to CL caused by L. tropica ." @default.
- W3089839475 created "2020-10-08" @default.
- W3089839475 creator A5015309411 @default.
- W3089839475 creator A5018258697 @default.
- W3089839475 creator A5019810509 @default.
- W3089839475 creator A5039473328 @default.
- W3089839475 creator A5045405162 @default.
- W3089839475 creator A5045644761 @default.
- W3089839475 creator A5050607478 @default.
- W3089839475 creator A5078905826 @default.
- W3089839475 creator A5080484958 @default.
- W3089839475 creator A5084929052 @default.
- W3089839475 creator A5087793433 @default.
- W3089839475 creator A5089355752 @default.
- W3089839475 creator A5089715150 @default.
- W3089839475 date "2020-10-01" @default.
- W3089839475 modified "2023-10-12" @default.
- W3089839475 title "Molecular signatures of anthroponotic cutaneous leishmaniasis in the lesions of patients infected with Leishmania tropica" @default.
- W3089839475 cites W1569522228 @default.
- W3089839475 cites W1776893163 @default.
- W3089839475 cites W1918126302 @default.
- W3089839475 cites W1952035618 @default.
- W3089839475 cites W1965454317 @default.
- W3089839475 cites W1984782555 @default.
- W3089839475 cites W1987724206 @default.
- W3089839475 cites W2014535116 @default.
- W3089839475 cites W2016483136 @default.
- W3089839475 cites W2020946274 @default.
- W3089839475 cites W2035618305 @default.
- W3089839475 cites W2044620859 @default.
- W3089839475 cites W2052340028 @default.
- W3089839475 cites W2054943138 @default.
- W3089839475 cites W2057149484 @default.
- W3089839475 cites W2065688950 @default.
- W3089839475 cites W2095673806 @default.
- W3089839475 cites W2096627143 @default.
- W3089839475 cites W2097590400 @default.
- W3089839475 cites W2109521866 @default.
- W3089839475 cites W2110252365 @default.
- W3089839475 cites W2115452562 @default.
- W3089839475 cites W2130410032 @default.
- W3089839475 cites W2134526812 @default.
- W3089839475 cites W2140099276 @default.
- W3089839475 cites W2158804744 @default.
- W3089839475 cites W2169456326 @default.
- W3089839475 cites W2172557341 @default.
- W3089839475 cites W2179438025 @default.
- W3089839475 cites W2343795213 @default.
- W3089839475 cites W2384133405 @default.
- W3089839475 cites W2399401760 @default.
- W3089839475 cites W2519112974 @default.
- W3089839475 cites W2528544269 @default.
- W3089839475 cites W2585366625 @default.
- W3089839475 cites W2605588409 @default.
- W3089839475 cites W2619856908 @default.
- W3089839475 cites W2732736846 @default.
- W3089839475 cites W2735115117 @default.
- W3089839475 cites W2748988353 @default.
- W3089839475 cites W2755736976 @default.
- W3089839475 cites W2792732840 @default.
- W3089839475 cites W2795214533 @default.
- W3089839475 cites W2804968926 @default.
- W3089839475 cites W2805217220 @default.
- W3089839475 cites W2807103672 @default.
- W3089839475 cites W2808036105 @default.
- W3089839475 cites W2889791161 @default.
- W3089839475 cites W2890640294 @default.
- W3089839475 cites W2891619385 @default.
- W3089839475 cites W2906179959 @default.
- W3089839475 cites W2907780763 @default.
- W3089839475 cites W2909485498 @default.
- W3089839475 cites W2913965697 @default.
- W3089839475 cites W2920688815 @default.
- W3089839475 cites W2920836773 @default.
- W3089839475 cites W2922504778 @default.
- W3089839475 cites W2923404982 @default.
- W3089839475 cites W2923545753 @default.
- W3089839475 cites W2924427186 @default.
- W3089839475 cites W2943179680 @default.
- W3089839475 cites W2943262156 @default.
- W3089839475 cites W2944510560 @default.
- W3089839475 cites W2990679902 @default.
- W3089839475 cites W2997273999 @default.
- W3089839475 cites W4297678774 @default.
- W3089839475 cites W988142379 @default.
- W3089839475 doi "https://doi.org/10.1038/s41598-020-72671-7" @default.
- W3089839475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529897" @default.
- W3089839475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33004861" @default.
- W3089839475 hasPublicationYear "2020" @default.
- W3089839475 type Work @default.
- W3089839475 sameAs 3089839475 @default.
- W3089839475 citedByCount "10" @default.
- W3089839475 countsByYear W30898394752020 @default.
- W3089839475 countsByYear W30898394752021 @default.
- W3089839475 countsByYear W30898394752022 @default.
- W3089839475 countsByYear W30898394752023 @default.
- W3089839475 crossrefType "journal-article" @default.
- W3089839475 hasAuthorship W3089839475A5015309411 @default.
- W3089839475 hasAuthorship W3089839475A5018258697 @default.
- W3089839475 hasAuthorship W3089839475A5019810509 @default.