FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089845178> ?p ?o ?g. }

• W3089845178 endingPage "731" @default.
• W3089845178 startingPage "723" @default.
• W3089845178 abstract "Acute respiratory distress syndrome (ARDS) is multiple inflammatory injury lung disease. MiR-27a-3p alleviates lung injury, whether miR-27a-3p could affect the lung inflammation is not clear. Therefore, we established the lipopolysaccharides (LPS)-induced alveolar epithelial cell model to simulate ARDS inflammation in vitro to investigate the effect of miR-27a-3p in ARDS. After LPS-induced alveolar epithelial cell model was established and FOXO3 was proved to be targeted by miR-27a-3p, the miR-27a-3p mimic, inhibitor, or FOXO3-overexpression plasmids were transfected into the cells. The effects of miR-27a-3p and FOXO3 on cell viability and apoptosis were then evaluated. The levels of apoptosis-/inflammation-related factors, miR-27a-3p, and FOXO3 were further analyzed. Also, the activities of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NAPDH) in cells were examined. MiR-27a-3p was down-regulated in LPS-induced alveolar epithelial cells. The decreased-cell viability of the LPS-induced cells was increased by miR-27a-3p mimic while inhibited by FOXO3. The enhanced-apoptosis, and up-regulated Bax and C caspase-3 were reduced by miR-27a-3p mimic while inhibited by FOXO3; the down-regulated Bcl-2 of the LPS-induced cells was increased by miR-27a-3p mimic while inhibited by FOXO3. The up-regulated IL-6, IL-8, ROS, and NAPDH in the LPS-induced cells were reduced by miR-27a-3p mimic while inhibited by FOXO3. Besides, FOXO3 reversed the effect of miR-27a-3p mimic on the LPS-induced cells. MiR-27a-3p targeted FOXO3 to mitigated inflammation and apoptosis of LPS-induced alveolar epithelial cells via suppressing NAPDH/ROS activation." @default.
• W3089845178 created "2020-10-08" @default.
• W3089845178 creator A5006218564 @default.
• W3089845178 creator A5006758496 @default.
• W3089845178 creator A5022703030 @default.
• W3089845178 creator A5051084267 @default.
• W3089845178 creator A5073216396 @default.
• W3089845178 creator A5085095982 @default.
• W3089845178 creator A5086184359 @default.
• W3089845178 date "2020-12-01" @default.
• W3089845178 modified "2023-10-12" @default.
• W3089845178 title "MiR-27a-3p overexpression mitigates inflammation and apoptosis of lipopolysaccharides-induced alveolar epithelial cells by targeting FOXO3 and suppressing the activation of NAPDH/ROS" @default.
• W3089845178 cites W2227985055 @default.
• W3089845178 cites W2288482887 @default.
• W3089845178 cites W2467622083 @default.
• W3089845178 cites W2537790317 @default.
• W3089845178 cites W2600561071 @default.
• W3089845178 cites W2601013458 @default.
• W3089845178 cites W2769551956 @default.
• W3089845178 cites W2795268824 @default.
• W3089845178 cites W2811446453 @default.
• W3089845178 cites W2906035087 @default.
• W3089845178 cites W2921489683 @default.
• W3089845178 cites W2923585401 @default.
• W3089845178 cites W2985620787 @default.
• W3089845178 cites W2996614227 @default.
• W3089845178 cites W2997774493 @default.
• W3089845178 cites W3011047309 @default.
• W3089845178 cites W3023073492 @default.
• W3089845178 cites W4211250103 @default.
• W3089845178 cites W4237939525 @default.
• W3089845178 doi "https://doi.org/10.1016/j.bbrc.2020.07.126" @default.
• W3089845178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32993961" @default.
• W3089845178 hasPublicationYear "2020" @default.
• W3089845178 type Work @default.
• W3089845178 sameAs 3089845178 @default.
• W3089845178 citedByCount "12" @default.
• W3089845178 countsByYear W30898451782021 @default.
• W3089845178 countsByYear W30898451782022 @default.
• W3089845178 countsByYear W30898451782023 @default.
• W3089845178 crossrefType "journal-article" @default.
• W3089845178 hasAuthorship W3089845178A5006218564 @default.
• W3089845178 hasAuthorship W3089845178A5006758496 @default.
• W3089845178 hasAuthorship W3089845178A5022703030 @default.
• W3089845178 hasAuthorship W3089845178A5051084267 @default.
• W3089845178 hasAuthorship W3089845178A5073216396 @default.
• W3089845178 hasAuthorship W3089845178A5085095982 @default.
• W3089845178 hasAuthorship W3089845178A5086184359 @default.
• W3089845178 hasConcept C126322002 @default.
• W3089845178 hasConcept C153911025 @default.
• W3089845178 hasConcept C168003608 @default.
• W3089845178 hasConcept C185592680 @default.
• W3089845178 hasConcept C190283241 @default.
• W3089845178 hasConcept C203014093 @default.
• W3089845178 hasConcept C2776348555 @default.
• W3089845178 hasConcept C2776914184 @default.
• W3089845178 hasConcept C2777714996 @default.
• W3089845178 hasConcept C48349386 @default.
• W3089845178 hasConcept C502942594 @default.
• W3089845178 hasConcept C53227056 @default.
• W3089845178 hasConcept C54009773 @default.
• W3089845178 hasConcept C54355233 @default.
• W3089845178 hasConcept C55493867 @default.
• W3089845178 hasConcept C71924100 @default.
• W3089845178 hasConcept C75217442 @default.
• W3089845178 hasConcept C81729549 @default.
• W3089845178 hasConcept C81885089 @default.
• W3089845178 hasConcept C86803240 @default.
• W3089845178 hasConcept C95444343 @default.
• W3089845178 hasConceptScore W3089845178C126322002 @default.
• W3089845178 hasConceptScore W3089845178C153911025 @default.
• W3089845178 hasConceptScore W3089845178C168003608 @default.
• W3089845178 hasConceptScore W3089845178C185592680 @default.
• W3089845178 hasConceptScore W3089845178C190283241 @default.
• W3089845178 hasConceptScore W3089845178C203014093 @default.
• W3089845178 hasConceptScore W3089845178C2776348555 @default.
• W3089845178 hasConceptScore W3089845178C2776914184 @default.
• W3089845178 hasConceptScore W3089845178C2777714996 @default.
• W3089845178 hasConceptScore W3089845178C48349386 @default.
• W3089845178 hasConceptScore W3089845178C502942594 @default.
• W3089845178 hasConceptScore W3089845178C53227056 @default.
• W3089845178 hasConceptScore W3089845178C54009773 @default.
• W3089845178 hasConceptScore W3089845178C54355233 @default.
• W3089845178 hasConceptScore W3089845178C55493867 @default.
• W3089845178 hasConceptScore W3089845178C71924100 @default.
• W3089845178 hasConceptScore W3089845178C75217442 @default.
• W3089845178 hasConceptScore W3089845178C81729549 @default.
• W3089845178 hasConceptScore W3089845178C81885089 @default.
• W3089845178 hasConceptScore W3089845178C86803240 @default.
• W3089845178 hasConceptScore W3089845178C95444343 @default.
• W3089845178 hasFunder F4320338464 @default.
• W3089845178 hasIssue "4" @default.
• W3089845178 hasLocation W30898451781 @default.
• W3089845178 hasOpenAccess W3089845178 @default.
• W3089845178 hasPrimaryLocation W30898451781 @default.
• W3089845178 hasRelatedWork W2353706338 @default.
• W3089845178 hasRelatedWork W2406153264 @default.
• W3089845178 hasRelatedWork W2540815636 @default.

• next