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• W3089850004 abstract "Background and Aim: Delay on admission of myocardial infarction (MI) is an important prognostic factor In this nationwide registry, we compared treatment delays and outcomes of patients with acute MI in Covid-19 pandemic period with a recent pre-pandemic registry conducted at the same centers Methods: A recent nationwide registry (TURKMI-1) enrolled consecutive patients with acute MI in November 1-15, 2018 in Turkey, and assessed time delay at each step from symptom-onset to treatment and outcomes Fifty centers were selected using probability sampling In the present study (TURKMI-2), the same information was obtained from 48 of the same 50 centers during the pandemic between April 17 and May 2, 2020 Results: In a 2-week period, 991 patients (51 1% NSTEMI, 48 9% STEMI) were admitted to the study centers within the 48-hour of symptom-onset Compared with the TURKMI-1, admissions decreased by 31 2% in ST-segment elevation MI (STEMI), and 56 4% in non-STEMI (NSTEMI) (Figure 1) Median time from symptom-onset to hospital-arrival increased from 295 min to 419 min in NSTEMI, and from 150 min to 185 min in STEMI (p-values <0 001) Door-to-balloon time was similar in the two periods (37 vs 40 min, p=0 448), however, total ischemic time increased significantly (195 min vs 245 min, p=0 001) mainly due to patient-related delay (figure 2,3) Percutaneous coronary intervention (PCI) was decreased especially in the NSTEMI group (60 3% vs 47 4% in NSTEMI, p<0 001;94 8% vs 91 1% in STEMI, p=0 013) Major cardiac adverse events (MACE) defined as in-hospital death, heart failure, or cardiogenic shock were significantly higher in the pandemic period compared to non-pandemic (4 8% vs 8 9%;p<0 001) Age and sex adjusted risk of MACE was two times higher during pandemic (Odds ratio [95% confidence interval] was 1 96 [1 20-3 22] for NSTEMI, p=0 007;and 2 08 [1 38-3 13] for STEMI, p<0 001) (figure 4) Conclusions: Besides the overall 47 1% reduction in acute MI admissions, there was a significant patient related treatment delay during the pandemic Although PCI was performed in a timely fashion, increase in total ischemic time and decrease in PCI might be responsible for the increased risk of MACE in acute MI" @default.
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• W3089850004 date "2020-01-01" @default.
• W3089850004 modified "2023-10-17" @default.
• W3089850004 title "Treatment Delays and In-Hospital Outcomes In Acute Myocardial Infarction During The Covid-19 Pandemic: A Nationwide Study" @default.
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• W3089850004 doi "https://doi.org/10.14744/anatoljcardiol.2020.98607" @default.
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