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- W3089853008 abstract "Abstract Ewing sarcoma is an aggressive pediatric tumor of the bone and soft tissue. The current standard of care is radiation and chemotherapy, and patients generally lack targeted therapies. One of the defining molecular features of this tumor type is the presence of significantly elevated levels of replication stress as compared with both normal cells and many other types of cancers, but the source of this stress is poorly understood. Tumors that harbor elevated levels of replication stress rely on the replication stress and DNA damage response pathways to retain viability. Understanding the source of the replication stress in Ewing sarcoma may reveal novel therapeutic targets. Ewing sarcomagenesis is complex, and in this review, we discuss the current state of our knowledge regarding elevated replication stress and the DNA damage response in Ewing sarcoma, one contributor to the disease process. We will also describe how these pathways are being successfully targeted therapeutically in other tumor types, and discuss possible novel, evidence-based therapeutic interventions in Ewing sarcoma. We hope that this consolidation will spark investigations that uncover new therapeutic targets and lead to the development of better treatment options for patients with Ewing sarcoma. Implications: This review uncovers new therapeutic targets in Ewing sarcoma and highlights replication stress as an exploitable vulnerability across multiple cancers." @default.
- W3089853008 created "2020-10-08" @default.
- W3089853008 creator A5009301444 @default.
- W3089853008 creator A5025397230 @default.
- W3089853008 creator A5029365707 @default.
- W3089853008 creator A5049137444 @default.
- W3089853008 creator A5057901093 @default.
- W3089853008 creator A5078772561 @default.
- W3089853008 date "2021-02-01" @default.
- W3089853008 modified "2023-10-16" @default.
- W3089853008 title "Exploiting Replication Stress as a Novel Therapeutic Intervention" @default.
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