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- W3089898280 endingPage "252" @default.
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- W3089898280 abstract "Abstract Thiol-based redox switches evolved as efficient post-translational regulatory mechanisms that enable individual proteins to rapidly respond to sudden environmental changes. While some protein functions need to be switched off to save resources and avoid potentially error-prone processes, protective functions become essential and need to be switched on. In this review, we focus on thiol-based activation mechanisms of stress-sensing chaperones. Upon stress exposure, these chaperones convert into high affinity binding platforms for unfolding proteins and protect cells against the accumulation of potentially toxic protein aggregates. Their chaperone activity is independent of ATP, a feature that becomes especially important under oxidative stress conditions, where cellular ATP levels drop and canonical ATP-dependent chaperones no longer operate. Vice versa , reductive inactivation and substrate release require the restoration of ATP levels, which ensures refolding of client proteins by ATP-dependent foldases. We will give an overview over the different strategies that cells evolved to rapidly increase the pool of ATP-independent chaperones upon oxidative stress and provide mechanistic insights into how stress conditions are used to convert abundant cellular proteins into ATP-independent holding chaperones." @default.
- W3089898280 created "2020-10-08" @default.
- W3089898280 creator A5006852686 @default.
- W3089898280 creator A5046177432 @default.
- W3089898280 creator A5052886243 @default.
- W3089898280 date "2020-10-05" @default.
- W3089898280 modified "2023-10-16" @default.
- W3089898280 title "Thiol-based switching mechanisms of stress-sensing chaperones" @default.
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