FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089965722> ?p ?o ?g. }

• W3089965722 endingPage "e1008849" @default.
• W3089965722 startingPage "e1008849" @default.
• W3089965722 abstract "Epstein-Barr virus (EBV) causes lymphomas and epithelial cell cancers. Though generally silent in B lymphocytes, this widely prevalent virus can cause endemic Burkitt lymphoma and post-transplant lymphoproliferative disorders/lymphomas in immunocompromised hosts. By learning how EBV breaches barriers to cell proliferation, we hope to undermine those strategies to treat EBV lymphomas and potentially other cancers. We had previously found that EBV, through activation of cellular STAT3 prevents phosphorylation of Chk1, and thereby, suppresses activation of the intra-S phase cell-cycle checkpoint, a potent barrier to oncogene-driven proliferation. This observation prompted us to examine the consequences on DNA repair since homologous recombination repair, the most error-free form, requires phosphoChk1. We now report that the defect in Chk1 phosphorylation also curtails RAD51 nucleation, and thereby, homologous recombination repair of DNA double strand breaks. The resulting reliance on error-prone microhomology-mediated end-joining (MMEJ) repair makes EBV-transformed cells susceptible to PARP inhibition and simultaneous accrual of genome-wide deletions and insertions resulting from synthesis-dependent MMEJ. Analysis of transcriptomic and drug susceptibility data from hundreds of cancer lines reveals a STAT3-dependent gene-set predictive of susceptibility of cancers to synthetic lethal PARP inhibition. These findings i) demonstrate how the tumor virus EBV re-shapes cellular DNA repair, ii) provide the first genome-wide evidence for insertions resulting from MMEJ in human cells, and iii) expand the range of cancers (EBV-related and -unrelated) that are likely to respond to synthetic lethal inhibitors given the high prevalence of cancers with constitutively active STAT3." @default.
• W3089965722 created "2020-10-08" @default.
• W3089965722 creator A5010903349 @default.
• W3089965722 creator A5015173460 @default.
• W3089965722 creator A5018503049 @default.
• W3089965722 creator A5019082613 @default.
• W3089965722 creator A5020207988 @default.
• W3089965722 creator A5031566985 @default.
• W3089965722 creator A5048939232 @default.
• W3089965722 creator A5049591962 @default.
• W3089965722 creator A5070606861 @default.
• W3089965722 creator A5070802733 @default.
• W3089965722 creator A5077350075 @default.
• W3089965722 creator A5087526251 @default.
• W3089965722 date "2020-10-01" @default.
• W3089965722 modified "2023-10-15" @default.
• W3089965722 title "STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes" @default.
• W3089965722 cites W1536338076 @default.
• W3089965722 cites W1544691147 @default.
• W3089965722 cites W1548640328 @default.
• W3089965722 cites W1659768997 @default.
• W3089965722 cites W168754456 @default.
• W3089965722 cites W1755903939 @default.
• W3089965722 cites W1964742429 @default.
• W3089965722 cites W1969294545 @default.
• W3089965722 cites W1972171708 @default.
• W3089965722 cites W1975473230 @default.
• W3089965722 cites W1979401674 @default.
• W3089965722 cites W2002962154 @default.
• W3089965722 cites W2013078073 @default.
• W3089965722 cites W2022309076 @default.
• W3089965722 cites W2028716241 @default.
• W3089965722 cites W2044706261 @default.
• W3089965722 cites W2051301388 @default.
• W3089965722 cites W2052908887 @default.
• W3089965722 cites W2068668324 @default.
• W3089965722 cites W2073770292 @default.
• W3089965722 cites W2077721448 @default.
• W3089965722 cites W2083960841 @default.
• W3089965722 cites W2100419317 @default.
• W3089965722 cites W2110817748 @default.
• W3089965722 cites W2113704699 @default.
• W3089965722 cites W2116326380 @default.
• W3089965722 cites W2122825543 @default.
• W3089965722 cites W2125789330 @default.
• W3089965722 cites W2127048642 @default.
• W3089965722 cites W2129753373 @default.
• W3089965722 cites W2135046866 @default.
• W3089965722 cites W2135340562 @default.
• W3089965722 cites W2142658272 @default.
• W3089965722 cites W2149795092 @default.
• W3089965722 cites W2152061559 @default.
• W3089965722 cites W2155767198 @default.
• W3089965722 cites W2156077962 @default.
• W3089965722 cites W2162721157 @default.
• W3089965722 cites W2168396953 @default.
• W3089965722 cites W2168518606 @default.
• W3089965722 cites W2203229763 @default.
• W3089965722 cites W2429819149 @default.
• W3089965722 cites W2510304580 @default.
• W3089965722 cites W2528228811 @default.
• W3089965722 cites W2593659832 @default.
• W3089965722 cites W2749641460 @default.
• W3089965722 cites W2767848910 @default.
• W3089965722 cites W2797366162 @default.
• W3089965722 cites W2884301740 @default.
• W3089965722 cites W2888204442 @default.
• W3089965722 cites W2900248192 @default.
• W3089965722 cites W2921779622 @default.
• W3089965722 cites W2994496141 @default.
• W3089965722 doi "https://doi.org/10.1371/journal.ppat.1008849" @default.
• W3089965722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529304" @default.
• W3089965722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33002095" @default.
• W3089965722 hasPublicationYear "2020" @default.
• W3089965722 type Work @default.
• W3089965722 sameAs 3089965722 @default.
• W3089965722 citedByCount "6" @default.
• W3089965722 countsByYear W30899657222022 @default.
• W3089965722 countsByYear W30899657222023 @default.
• W3089965722 crossrefType "journal-article" @default.
• W3089965722 hasAuthorship W3089965722A5010903349 @default.
• W3089965722 hasAuthorship W3089965722A5015173460 @default.
• W3089965722 hasAuthorship W3089965722A5018503049 @default.
• W3089965722 hasAuthorship W3089965722A5019082613 @default.
• W3089965722 hasAuthorship W3089965722A5020207988 @default.
• W3089965722 hasAuthorship W3089965722A5031566985 @default.
• W3089965722 hasAuthorship W3089965722A5048939232 @default.
• W3089965722 hasAuthorship W3089965722A5049591962 @default.
• W3089965722 hasAuthorship W3089965722A5070606861 @default.
• W3089965722 hasAuthorship W3089965722A5070802733 @default.
• W3089965722 hasAuthorship W3089965722A5077350075 @default.
• W3089965722 hasAuthorship W3089965722A5087526251 @default.
• W3089965722 hasBestOaLocation W30899657221 @default.
• W3089965722 hasConcept C102744134 @default.
• W3089965722 hasConcept C104317684 @default.
• W3089965722 hasConcept C156695909 @default.
• W3089965722 hasConcept C159047783 @default.
• W3089965722 hasConcept C2522874641 @default.

• next