FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089969311> ?p ?o ?g. }

• W3089969311 abstract "Dengue virus (DENV) is a mosquito-borne pathogen that threatens 2.5 billion people in more than 100 countries annually. Dengue infection induces a spectrum of clinical symptoms, ranging from classical dengue fever to severe dengue hemorrhagic fever or dengue shock syndrome; however, the complexities of DENV immunopathogenesis remain controversial. Previous studies have reported the importance of the transcription factor Nrf2 in the control of redox homeostasis and antiviral/inflammatory or death responses to DENV. Importantly, the production of reactive oxygen species and the subsequent stress response have been linked to the development of inflammation and progression toward the more severe forms of the disease. Here, we demonstrate that DENV uses the NS2B3 protease complex to strategically target Nrf2 for degradation, leading to a progressive increase in oxidative stress, inflammation, and cell death in infected cells. This study underlines the pivotal role of the Nrf2 regulatory network in the context of DENV infection." @default.
• W3089969311 created "2020-10-08" @default.
• W3089969311 creator A5000811036 @default.
• W3089969311 creator A5006408418 @default.
• W3089969311 creator A5009033820 @default.
• W3089969311 creator A5013664458 @default.
• W3089969311 creator A5017539817 @default.
• W3089969311 creator A5026779976 @default.
• W3089969311 creator A5027741209 @default.
• W3089969311 creator A5042737704 @default.
• W3089969311 creator A5056426167 @default.
• W3089969311 creator A5059680550 @default.
• W3089969311 creator A5066820575 @default.
• W3089969311 creator A5077660812 @default.
• W3089969311 creator A5085313296 @default.
• W3089969311 date "2020-11-23" @default.
• W3089969311 modified "2023-10-06" @default.
• W3089969311 title "Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication" @default.
• W3089969311 cites W1513149807 @default.
• W3089969311 cites W1597991178 @default.
• W3089969311 cites W1758390239 @default.
• W3089969311 cites W1767659454 @default.
• W3089969311 cites W1854967502 @default.
• W3089969311 cites W1983101236 @default.
• W3089969311 cites W1986683147 @default.
• W3089969311 cites W1998911549 @default.
• W3089969311 cites W2004739896 @default.
• W3089969311 cites W2007396482 @default.
• W3089969311 cites W2008344420 @default.
• W3089969311 cites W2009080092 @default.
• W3089969311 cites W2012156061 @default.
• W3089969311 cites W2015243552 @default.
• W3089969311 cites W2031454744 @default.
• W3089969311 cites W2035676834 @default.
• W3089969311 cites W2038554008 @default.
• W3089969311 cites W2039409172 @default.
• W3089969311 cites W2042288808 @default.
• W3089969311 cites W2043930556 @default.
• W3089969311 cites W2046757730 @default.
• W3089969311 cites W2053047691 @default.
• W3089969311 cites W2062343812 @default.
• W3089969311 cites W2062392726 @default.
• W3089969311 cites W2064815984 @default.
• W3089969311 cites W2066980314 @default.
• W3089969311 cites W2071154789 @default.
• W3089969311 cites W2075855311 @default.
• W3089969311 cites W2081020320 @default.
• W3089969311 cites W2087948760 @default.
• W3089969311 cites W2089032508 @default.
• W3089969311 cites W2089035516 @default.
• W3089969311 cites W2091089657 @default.
• W3089969311 cites W2094026727 @default.
• W3089969311 cites W2096649701 @default.
• W3089969311 cites W2099792161 @default.
• W3089969311 cites W2100139577 @default.
• W3089969311 cites W2100720499 @default.
• W3089969311 cites W2102354517 @default.
• W3089969311 cites W2115146089 @default.
• W3089969311 cites W2115681402 @default.
• W3089969311 cites W2117410303 @default.
• W3089969311 cites W2121386867 @default.
• W3089969311 cites W2126558789 @default.
• W3089969311 cites W2126635195 @default.
• W3089969311 cites W2127036378 @default.
• W3089969311 cites W2131222241 @default.
• W3089969311 cites W2134703818 @default.
• W3089969311 cites W2146006596 @default.
• W3089969311 cites W2147587904 @default.
• W3089969311 cites W2149459759 @default.
• W3089969311 cites W2153059926 @default.
• W3089969311 cites W2161690855 @default.
• W3089969311 cites W2162757298 @default.
• W3089969311 cites W2165956966 @default.
• W3089969311 cites W2170642272 @default.
• W3089969311 cites W2172793519 @default.
• W3089969311 cites W2331948955 @default.
• W3089969311 cites W2361586644 @default.
• W3089969311 cites W2487655429 @default.
• W3089969311 cites W2509430738 @default.
• W3089969311 cites W2509562754 @default.
• W3089969311 cites W2536931592 @default.
• W3089969311 cites W2573203202 @default.
• W3089969311 cites W2603207919 @default.
• W3089969311 cites W2617530769 @default.
• W3089969311 cites W2617995385 @default.
• W3089969311 cites W2619994071 @default.
• W3089969311 cites W2767582873 @default.
• W3089969311 cites W2794844698 @default.
• W3089969311 cites W2884914606 @default.
• W3089969311 cites W2888230285 @default.
• W3089969311 cites W2915965882 @default.
• W3089969311 cites W2948787844 @default.
• W3089969311 cites W4236372612 @default.
• W3089969311 doi "https://doi.org/10.1128/jvi.01551-20" @default.
• W3089969311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7925186" @default.
• W3089969311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32999020" @default.
• W3089969311 hasPublicationYear "2020" @default.
• W3089969311 type Work @default.
• W3089969311 sameAs 3089969311 @default.
• W3089969311 citedByCount "28" @default.

• next