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- W3089988619 endingPage "1115" @default.
- W3089988619 startingPage "1115" @default.
- W3089988619 abstract "Nearly all retroviruses selectively package two copies of their unspliced RNA genomes from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs. Over the past four decades, combinations of genetic experiments, phylogenetic analyses, nucleotide accessibility mapping, in silico RNA structure predictions, and biophysical experiments were employed to understand how retroviral genomes are selected for packaging. Genetic studies provided early clues regarding the protein and RNA elements required for packaging, and nucleotide accessibility mapping experiments provided insights into the secondary structures of functionally important elements in the genome. Three-dimensional structural determinants of packaging were primarily derived by nuclear magnetic resonance (NMR) spectroscopy. A key advantage of NMR, relative to other methods for determining biomolecular structure (such as X-ray crystallography), is that it is well suited for studies of conformationally dynamic and heterogeneous systems—a hallmark of the retrovirus packaging machinery. Here, we review advances in understanding of the structures, dynamics, and interactions of the proteins and RNA elements involved in retroviral genome selection and packaging that are facilitated by NMR." @default.
- W3089988619 created "2020-10-08" @default.
- W3089988619 creator A5002017144 @default.
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- W3089988619 creator A5080308512 @default.
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- W3089988619 date "2020-09-30" @default.
- W3089988619 modified "2023-10-15" @default.
- W3089988619 title "NMR Studies of Retroviral Genome Packaging" @default.
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