FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090036866> ?p ?o ?g. }

• W3090036866 endingPage "e1008929" @default.
• W3090036866 startingPage "e1008929" @default.
• W3090036866 abstract "The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM), which are favorable to Mtb. The activation state of macrophages is tightly associated to different metabolic pathways, such as lipid metabolism, but whether differentiation towards FM differs between the macrophage activation profiles remains unclear. Here, we aimed to elucidate whether distinct macrophage activation states exposed to a tuberculosis-associated microenvironment or directly infected with Mtb can form FM. We showed that the triggering of signal transducer and activator of transcription 6 (STAT6) in interleukin (IL)-4-activated human macrophages (M(IL-4)) prevents FM formation induced by pleural effusion from patients with tuberculosis. In these cells, LBs are disrupted by lipolysis, and the released fatty acids enter the β-oxidation (FAO) pathway fueling the generation of ATP in mitochondria. Accordingly, murine alveolar macrophages, which exhibit a predominant FAO metabolism, are less prone to become FM than bone marrow derived-macrophages. Interestingly, direct infection of M(IL-4) macrophages with Mtb results in the establishment of aerobic glycolytic pathway and FM formation, which could be prevented by FAO activation or inhibition of the hypoxia-inducible factor 1-alpha (HIF-1α)-induced glycolytic pathway. In conclusion, our results demonstrate that Mtb has a remarkable capacity to induce FM formation through the rewiring of metabolic pathways in human macrophages, including the STAT6-driven alternatively activated program. This study provides key insights into macrophage metabolism and pathogen subversion strategies." @default.
• W3090036866 created "2020-10-08" @default.
• W3090036866 creator A5007007507 @default.
• W3090036866 creator A5013048575 @default.
• W3090036866 creator A5013075837 @default.
• W3090036866 creator A5021648205 @default.
• W3090036866 creator A5022219482 @default.
• W3090036866 creator A5025210231 @default.
• W3090036866 creator A5026070004 @default.
• W3090036866 creator A5031135267 @default.
• W3090036866 creator A5038070846 @default.
• W3090036866 creator A5046616343 @default.
• W3090036866 creator A5047528016 @default.
• W3090036866 creator A5049101939 @default.
• W3090036866 creator A5052882553 @default.
• W3090036866 creator A5054807531 @default.
• W3090036866 creator A5062581462 @default.
• W3090036866 creator A5065910864 @default.
• W3090036866 creator A5072738363 @default.
• W3090036866 creator A5088332737 @default.
• W3090036866 creator A5090839911 @default.
• W3090036866 date "2020-10-01" @default.
• W3090036866 modified "2023-10-07" @default.
• W3090036866 title "Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation" @default.
• W3090036866 cites W1996235861 @default.
• W3090036866 cites W2051139401 @default.
• W3090036866 cites W2135272175 @default.
• W3090036866 cites W2163376140 @default.
• W3090036866 cites W4252980734 @default.
• W3090036866 doi "https://doi.org/10.1371/journal.ppat.1008929" @default.
• W3090036866 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7553279" @default.
• W3090036866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33002063" @default.
• W3090036866 hasPublicationYear "2020" @default.
• W3090036866 type Work @default.
• W3090036866 sameAs 3090036866 @default.
• W3090036866 citedByCount "19" @default.
• W3090036866 countsByYear W30900368662019 @default.
• W3090036866 countsByYear W30900368662020 @default.
• W3090036866 countsByYear W30900368662021 @default.
• W3090036866 countsByYear W30900368662022 @default.
• W3090036866 countsByYear W30900368662023 @default.
• W3090036866 crossrefType "journal-article" @default.
• W3090036866 hasAuthorship W3090036866A5007007507 @default.
• W3090036866 hasAuthorship W3090036866A5013048575 @default.
• W3090036866 hasAuthorship W3090036866A5013075837 @default.
• W3090036866 hasAuthorship W3090036866A5021648205 @default.
• W3090036866 hasAuthorship W3090036866A5022219482 @default.
• W3090036866 hasAuthorship W3090036866A5025210231 @default.
• W3090036866 hasAuthorship W3090036866A5026070004 @default.
• W3090036866 hasAuthorship W3090036866A5031135267 @default.
• W3090036866 hasAuthorship W3090036866A5038070846 @default.
• W3090036866 hasAuthorship W3090036866A5046616343 @default.
• W3090036866 hasAuthorship W3090036866A5047528016 @default.
• W3090036866 hasAuthorship W3090036866A5049101939 @default.
• W3090036866 hasAuthorship W3090036866A5052882553 @default.
• W3090036866 hasAuthorship W3090036866A5054807531 @default.
• W3090036866 hasAuthorship W3090036866A5062581462 @default.
• W3090036866 hasAuthorship W3090036866A5065910864 @default.
• W3090036866 hasAuthorship W3090036866A5072738363 @default.
• W3090036866 hasAuthorship W3090036866A5088332737 @default.
• W3090036866 hasAuthorship W3090036866A5090839911 @default.
• W3090036866 hasBestOaLocation W30900368661 @default.
• W3090036866 hasConcept C142724271 @default.
• W3090036866 hasConcept C171958077 @default.
• W3090036866 hasConcept C185592680 @default.
• W3090036866 hasConcept C192989942 @default.
• W3090036866 hasConcept C20251656 @default.
• W3090036866 hasConcept C202751555 @default.
• W3090036866 hasConcept C2777975735 @default.
• W3090036866 hasConcept C2778923194 @default.
• W3090036866 hasConcept C2779244956 @default.
• W3090036866 hasConcept C2781069245 @default.
• W3090036866 hasConcept C4733338 @default.
• W3090036866 hasConcept C55493867 @default.
• W3090036866 hasConcept C62231903 @default.
• W3090036866 hasConcept C62478195 @default.
• W3090036866 hasConcept C71924100 @default.
• W3090036866 hasConcept C86803240 @default.
• W3090036866 hasConcept C95444343 @default.
• W3090036866 hasConceptScore W3090036866C142724271 @default.
• W3090036866 hasConceptScore W3090036866C171958077 @default.
• W3090036866 hasConceptScore W3090036866C185592680 @default.
• W3090036866 hasConceptScore W3090036866C192989942 @default.
• W3090036866 hasConceptScore W3090036866C20251656 @default.
• W3090036866 hasConceptScore W3090036866C202751555 @default.
• W3090036866 hasConceptScore W3090036866C2777975735 @default.
• W3090036866 hasConceptScore W3090036866C2778923194 @default.
• W3090036866 hasConceptScore W3090036866C2779244956 @default.
• W3090036866 hasConceptScore W3090036866C2781069245 @default.
• W3090036866 hasConceptScore W3090036866C4733338 @default.
• W3090036866 hasConceptScore W3090036866C55493867 @default.
• W3090036866 hasConceptScore W3090036866C62231903 @default.
• W3090036866 hasConceptScore W3090036866C62478195 @default.
• W3090036866 hasConceptScore W3090036866C71924100 @default.
• W3090036866 hasConceptScore W3090036866C86803240 @default.
• W3090036866 hasConceptScore W3090036866C95444343 @default.
• W3090036866 hasFunder F4320321594 @default.
• W3090036866 hasFunder F4320322892 @default.

• next