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- W3090099460 abstract "Between embryonic day 10.5 to 14.5, active proliferation drives rapid elongation of the murine midgut epithelial tube. Within this pseudostratified epithelium, nuclei synthesize DNA near the basal surface and move apically to divide. After mitosis, the majority of daughter cells extend a long, basally oriented filopodial protrusion, building a de novo path along which their nuclei can return to the basal side. WNT5A, secreted by surrounding mesenchymal cells, acts as a guidance cue to orchestrate this epithelial pathfinding behavior, but how this signal is received by epithelial cells is unknown. Here, we investigated two known WNT5A receptors, ROR2 and RYK. We found that epithelial ROR2 is dispensable for midgut elongation. However, loss of Ryk phenocopies the Wnt5a−/− phenotype, perturbing post-mitotic pathfinding and leading to apoptosis. These studies reveal that the ligand-receptor pair, WNT5A-RYK, acts as a navigation system to instruct filopodial pathfinding, a process critical for continuous cell cycling to fuel rapid midgut elongation." @default.
- W3090099460 created "2020-10-08" @default.
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- W3090099460 date "2020-01-01" @default.
- W3090099460 modified "2023-09-27" @default.
- W3090099460 title "RYK-mediated filopodial pathfinding facilitates midgut elongation" @default.
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- W3090099460 doi "https://doi.org/10.1242/dev.195388" @default.
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