Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090145982> ?p ?o ?g. }
- W3090145982 endingPage "3114" @default.
- W3090145982 startingPage "3104" @default.
- W3090145982 abstract "Oxidized LDLs (oxLDLs) and oxysterols play a key role in endothelial dysfunction and the development of atherosclerosis. The loss of vascular endothelium function negatively impacts vasomotion, cell growth, adhesiveness and barrier functions. While for some of these disturbances, a reasonable explanation can be provided from a mechanistic standpoint, for many others, the molecular mediators that are involved are unknown. Caveolae, specific plasma membrane domains, have recently emerged as targets and mediators of oxLDL‐induced endothelial dysfunction. Caveolae and their associated protein caveolin‐1 (Cav‐1) are involved in oxLDLs/LDLs transcytosis, mainly through the scavenger receptor class B type 1 (SR‐B1 or SCARB1). In contrast, oxLDLs endocytosis is mediated by the lectin‐like oxidized LDL receptor 1 (LOX‐1), whose activity depends on an intact caveolae system. In addition, LOX‐1 regulates the expression of Cav‐1 and vice versa. On the other hand, oxLDLs may affect cholesterol plasma membrane content/distribution thus influencing caveolae architecture, Cav‐1 localization and the associated signalling. Overall, the evidence indicate that caveolae have both active and passive roles in oxLDL‐induced endothelial cell dysfunction. First, as mediators of lipid uptake and transfer in the subendothelial space and, later, as targets of changes in composition/dynamics of plasma membrane lipids resulting from increased levels of circulating oxLDLs. Gaining a better understanding of how oxLDLs interact with endothelial cells and modulate caveolae‐mediated signalling pathways, leading to endothelial dysfunction, is crucial to find new targets for intervention to tackle atherosclerosis and the related clinical entities. LINKED ARTICLES This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.16/issuetoc" @default.
- W3090145982 created "2020-10-08" @default.
- W3090145982 creator A5000316085 @default.
- W3090145982 creator A5022034613 @default.
- W3090145982 creator A5023803862 @default.
- W3090145982 creator A5038526527 @default.
- W3090145982 creator A5041978951 @default.
- W3090145982 creator A5070911300 @default.
- W3090145982 creator A5078664682 @default.
- W3090145982 date "2020-10-18" @default.
- W3090145982 modified "2023-10-18" @default.
- W3090145982 title "LDL receptors, caveolae and cholesterol in endothelial dysfunction: oxLDLs accomplices or victims?" @default.
- W3090145982 cites W1505661009 @default.
- W3090145982 cites W1516421005 @default.
- W3090145982 cites W1549194476 @default.
- W3090145982 cites W1593026472 @default.
- W3090145982 cites W1964740564 @default.
- W3090145982 cites W1969075731 @default.
- W3090145982 cites W1971263149 @default.
- W3090145982 cites W1981616219 @default.
- W3090145982 cites W1982071275 @default.
- W3090145982 cites W1983465642 @default.
- W3090145982 cites W1984026469 @default.
- W3090145982 cites W1986958825 @default.
- W3090145982 cites W1990394155 @default.
- W3090145982 cites W1991469067 @default.
- W3090145982 cites W1994506978 @default.
- W3090145982 cites W1994559481 @default.
- W3090145982 cites W1994916925 @default.
- W3090145982 cites W1997119646 @default.
- W3090145982 cites W2000302106 @default.
- W3090145982 cites W2003688961 @default.
- W3090145982 cites W2005853229 @default.
- W3090145982 cites W2006359896 @default.
- W3090145982 cites W2012621840 @default.
- W3090145982 cites W2018956263 @default.
- W3090145982 cites W2022368219 @default.
- W3090145982 cites W2030698703 @default.
- W3090145982 cites W2032839318 @default.
- W3090145982 cites W2033048391 @default.
- W3090145982 cites W2038461285 @default.
- W3090145982 cites W2040025697 @default.
- W3090145982 cites W2044201289 @default.
- W3090145982 cites W2045773814 @default.
- W3090145982 cites W2046804517 @default.
- W3090145982 cites W2047171151 @default.
- W3090145982 cites W2050547021 @default.
- W3090145982 cites W2057440460 @default.
- W3090145982 cites W2060334268 @default.
- W3090145982 cites W2062667529 @default.
- W3090145982 cites W2066454958 @default.
- W3090145982 cites W2066820623 @default.
- W3090145982 cites W2070361680 @default.
- W3090145982 cites W2071279152 @default.
- W3090145982 cites W2074721095 @default.
- W3090145982 cites W2076185826 @default.
- W3090145982 cites W2077478792 @default.
- W3090145982 cites W2078370178 @default.
- W3090145982 cites W2080534792 @default.
- W3090145982 cites W2082268649 @default.
- W3090145982 cites W2083154566 @default.
- W3090145982 cites W2087821055 @default.
- W3090145982 cites W2091638984 @default.
- W3090145982 cites W2095480781 @default.
- W3090145982 cites W2098576019 @default.
- W3090145982 cites W2098879265 @default.
- W3090145982 cites W2103046581 @default.
- W3090145982 cites W2104500013 @default.
- W3090145982 cites W2104977728 @default.
- W3090145982 cites W2105341865 @default.
- W3090145982 cites W2111001050 @default.
- W3090145982 cites W2111279748 @default.
- W3090145982 cites W2112465136 @default.
- W3090145982 cites W2114623138 @default.
- W3090145982 cites W2116938869 @default.
- W3090145982 cites W2118038884 @default.
- W3090145982 cites W2131385716 @default.
- W3090145982 cites W2131745475 @default.
- W3090145982 cites W2133827326 @default.
- W3090145982 cites W2136418873 @default.
- W3090145982 cites W2137555841 @default.
- W3090145982 cites W2140538678 @default.
- W3090145982 cites W2140998385 @default.
- W3090145982 cites W2143142630 @default.
- W3090145982 cites W2145807969 @default.
- W3090145982 cites W2146190354 @default.
- W3090145982 cites W2146630844 @default.
- W3090145982 cites W2148772241 @default.
- W3090145982 cites W2149572998 @default.
- W3090145982 cites W2150677348 @default.
- W3090145982 cites W2154091874 @default.
- W3090145982 cites W2159250395 @default.
- W3090145982 cites W2161501228 @default.
- W3090145982 cites W2191035722 @default.
- W3090145982 cites W2290832747 @default.
- W3090145982 cites W2314465303 @default.
- W3090145982 cites W2341412675 @default.
- W3090145982 cites W2408233306 @default.