Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090209659> ?p ?o ?g. }
- W3090209659 endingPage "3352" @default.
- W3090209659 startingPage "3339" @default.
- W3090209659 abstract "Recent advances in the field of monodisperse microbubble synthesis by flow focusing allow for the production of foam-free, highly concentrated and monodisperse lipid-coated microbubble suspensions. It has been found that in vitro, such monodisperse ultrasound contrast agents (UCAs) improve the sensitivity of contrast-enhanced ultrasound imaging. Here, we present the first in vivo study in the left ventricle of rat and pig with this new monodisperse bubble agent. We systematically characterize the acoustic sensitivity and safety of the agent at an imaging frequency of 2.5 MHz as compared with three commercial polydisperse UCAs (SonoVue/Lumason, Definity/Luminity and Optison) and one research-grade polydisperse agent with the same shell composition as the monodisperse bubbles. The monodisperse microbubbles, which had a diameter of 4.2 μm, crossed the pulmonary vasculature, and their echo signal could be measured at least as long as that of the polydisperse UCAs, indicating that microfluidically formed monodisperse microbubbles are stable in vivo. Furthermore, it was found that the sensitivity of the monodisperse agent, expressed as the mean echo power per injected bubble, was at least 10 times higher than that of the polydisperse UCAs. Finally, the safety profile of the monodisperse microbubble suspension was evaluated by injecting 400 and 2000 times the imaging dose, and neither physiologic nor pathologic changes were found, which is a first indication that monodisperse lipid-coated microbubbles formed by flow focusing are safe for in vivo use. The more uniform acoustic response and corresponding increased imaging sensitivity of the monodisperse agent may boost emerging applications of microbubbles and ultrasound such as molecular imaging and therapy." @default.
- W3090209659 created "2020-10-08" @default.
- W3090209659 creator A5033584508 @default.
- W3090209659 creator A5045919969 @default.
- W3090209659 creator A5058032053 @default.
- W3090209659 creator A5072909346 @default.
- W3090209659 creator A5073992827 @default.
- W3090209659 creator A5085338236 @default.
- W3090209659 date "2020-12-01" @default.
- W3090209659 modified "2023-10-17" @default.
- W3090209659 title "Monodisperse versus Polydisperse Ultrasound Contrast Agents: In Vivo Sensitivity and safety in Rat and Pig" @default.
- W3090209659 cites W1765189520 @default.
- W3090209659 cites W1866759065 @default.
- W3090209659 cites W1887697009 @default.
- W3090209659 cites W1971661398 @default.
- W3090209659 cites W1972838826 @default.
- W3090209659 cites W1973652084 @default.
- W3090209659 cites W1974694293 @default.
- W3090209659 cites W1975272465 @default.
- W3090209659 cites W1979801398 @default.
- W3090209659 cites W1983101332 @default.
- W3090209659 cites W1985845218 @default.
- W3090209659 cites W1988734118 @default.
- W3090209659 cites W1991156563 @default.
- W3090209659 cites W1995295355 @default.
- W3090209659 cites W1996401428 @default.
- W3090209659 cites W1997551622 @default.
- W3090209659 cites W2002247276 @default.
- W3090209659 cites W2005085570 @default.
- W3090209659 cites W2008268209 @default.
- W3090209659 cites W2009434334 @default.
- W3090209659 cites W2013862338 @default.
- W3090209659 cites W2017459142 @default.
- W3090209659 cites W2018058835 @default.
- W3090209659 cites W2019640231 @default.
- W3090209659 cites W2021275436 @default.
- W3090209659 cites W2029902148 @default.
- W3090209659 cites W2030773919 @default.
- W3090209659 cites W2036859909 @default.
- W3090209659 cites W2040160796 @default.
- W3090209659 cites W2044891747 @default.
- W3090209659 cites W2048391673 @default.
- W3090209659 cites W2061896383 @default.
- W3090209659 cites W2065264622 @default.
- W3090209659 cites W2070112477 @default.
- W3090209659 cites W2070672521 @default.
- W3090209659 cites W2072076646 @default.
- W3090209659 cites W2081462005 @default.
- W3090209659 cites W2083399669 @default.
- W3090209659 cites W2090478423 @default.
- W3090209659 cites W2090937981 @default.
- W3090209659 cites W2091593989 @default.
- W3090209659 cites W2093932324 @default.
- W3090209659 cites W2097583559 @default.
- W3090209659 cites W2100610949 @default.
- W3090209659 cites W2113569199 @default.
- W3090209659 cites W2129965454 @default.
- W3090209659 cites W2134178616 @default.
- W3090209659 cites W2136828611 @default.
- W3090209659 cites W2137249516 @default.
- W3090209659 cites W2137784828 @default.
- W3090209659 cites W2144118246 @default.
- W3090209659 cites W2153671281 @default.
- W3090209659 cites W2156360500 @default.
- W3090209659 cites W2166828306 @default.
- W3090209659 cites W2167389452 @default.
- W3090209659 cites W2170329132 @default.
- W3090209659 cites W2304649991 @default.
- W3090209659 cites W2329673071 @default.
- W3090209659 cites W2512809301 @default.
- W3090209659 cites W2530490267 @default.
- W3090209659 cites W2594287082 @default.
- W3090209659 cites W2610856665 @default.
- W3090209659 cites W2725898162 @default.
- W3090209659 cites W2751880771 @default.
- W3090209659 cites W2761553582 @default.
- W3090209659 cites W2790027452 @default.
- W3090209659 cites W2792790504 @default.
- W3090209659 cites W2800573830 @default.
- W3090209659 cites W2801186762 @default.
- W3090209659 cites W2806128337 @default.
- W3090209659 cites W2807112518 @default.
- W3090209659 cites W2896510812 @default.
- W3090209659 cites W2898594337 @default.
- W3090209659 cites W2899908543 @default.
- W3090209659 cites W2901983711 @default.
- W3090209659 cites W2910728952 @default.
- W3090209659 cites W2964228784 @default.
- W3090209659 cites W2982390406 @default.
- W3090209659 cites W2992332278 @default.
- W3090209659 cites W3000004257 @default.
- W3090209659 cites W3001285281 @default.
- W3090209659 cites W3011802638 @default.
- W3090209659 cites W3019353188 @default.
- W3090209659 cites W3035568990 @default.
- W3090209659 cites W3099654778 @default.
- W3090209659 doi "https://doi.org/10.1016/j.ultrasmedbio.2020.07.031" @default.
- W3090209659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33008649" @default.