FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090227473> ?p ?o ?g. }

• W3090227473 endingPage "384" @default.
• W3090227473 startingPage "378" @default.
• W3090227473 abstract "Ancient civilizations used natural products as food and as resources to treat various diseases. Today, food ingredients, especially those derived from plants, still play important roles in human nutrition and drug discovery. The health-promoting bioactive compounds or drug candidates need to be identified systematically and efficiently, for developing healthy diets and for alleviating the burden of chronic diseases worldwide. In this multi-disciplinary process, the separation and identification of diverse molecules, the analysis of their interactions with cellular targets, the chemical synthesis, and the animal and clinical trials, are all equally important. The focus of this mini-review is on the initial stage of the process, which is critical to future trends of health foods and food-derived drug discoveries. Through the strategy of targeting the critical proteins involved in many chronic diseases, the bioactive components can be fished out and studied further. Three of the major methodologies to accelerate the discovery of the bioactive components: high throughput screening, phage display technique and virtual screening, are summarized with successful examples. The efficient strategy to identify and further validate the cellular targets, the in silico target prediction and the mass spectroscopy-based proteomics, are also highlighted. To achieve this very promising research goals, through the strategy of targeting the critical proteins involved in many chronic diseases, the establishment of an International Food Ingredients Consortium (IFIC) is proposed." @default.
• W3090227473 created "2020-10-08" @default.
• W3090227473 creator A5013944987 @default.
• W3090227473 creator A5020939061 @default.
• W3090227473 creator A5048689093 @default.
• W3090227473 creator A5056345051 @default.
• W3090227473 creator A5069532552 @default.
• W3090227473 creator A5080853241 @default.
• W3090227473 date "2020-11-01" @default.
• W3090227473 modified "2023-09-23" @default.
• W3090227473 title "Target-based discovery of therapeutic agents from food ingredients" @default.
• W3090227473 cites W124230207 @default.
• W3090227473 cites W1489741616 @default.
• W3090227473 cites W1816068009 @default.
• W3090227473 cites W1860587896 @default.
• W3090227473 cites W1963912321 @default.
• W3090227473 cites W1968327387 @default.
• W3090227473 cites W1980047995 @default.
• W3090227473 cites W1986850261 @default.
• W3090227473 cites W1992450378 @default.
• W3090227473 cites W2003622911 @default.
• W3090227473 cites W2031390939 @default.
• W3090227473 cites W2035247391 @default.
• W3090227473 cites W2046182427 @default.
• W3090227473 cites W2046319392 @default.
• W3090227473 cites W2060542507 @default.
• W3090227473 cites W2070329956 @default.
• W3090227473 cites W2070360032 @default.
• W3090227473 cites W2076186247 @default.
• W3090227473 cites W2096859872 @default.
• W3090227473 cites W2106060578 @default.
• W3090227473 cites W2111581388 @default.
• W3090227473 cites W2121622799 @default.
• W3090227473 cites W2125033229 @default.
• W3090227473 cites W2176505599 @default.
• W3090227473 cites W2256742438 @default.
• W3090227473 cites W2278526984 @default.
• W3090227473 cites W2282933915 @default.
• W3090227473 cites W2336456779 @default.
• W3090227473 cites W2343443025 @default.
• W3090227473 cites W2403754224 @default.
• W3090227473 cites W2431662688 @default.
• W3090227473 cites W2575838842 @default.
• W3090227473 cites W2592822421 @default.
• W3090227473 cites W2594345796 @default.
• W3090227473 cites W2609441450 @default.
• W3090227473 cites W2707555017 @default.
• W3090227473 cites W2737143128 @default.
• W3090227473 cites W2769533173 @default.
• W3090227473 cites W2784729467 @default.
• W3090227473 cites W2787229753 @default.
• W3090227473 cites W2794929256 @default.
• W3090227473 cites W2799501495 @default.
• W3090227473 cites W2889049588 @default.
• W3090227473 cites W2909584276 @default.
• W3090227473 cites W2921329099 @default.
• W3090227473 cites W2924817651 @default.
• W3090227473 cites W2941469465 @default.
• W3090227473 cites W2968539995 @default.
• W3090227473 cites W2973123134 @default.
• W3090227473 cites W2982044300 @default.
• W3090227473 cites W2989870815 @default.
• W3090227473 cites W3011614894 @default.
• W3090227473 doi "https://doi.org/10.1016/j.tifs.2020.09.013" @default.
• W3090227473 hasPublicationYear "2020" @default.
• W3090227473 type Work @default.
• W3090227473 sameAs 3090227473 @default.
• W3090227473 citedByCount "0" @default.
• W3090227473 crossrefType "journal-article" @default.
• W3090227473 hasAuthorship W3090227473A5013944987 @default.
• W3090227473 hasAuthorship W3090227473A5020939061 @default.
• W3090227473 hasAuthorship W3090227473A5048689093 @default.
• W3090227473 hasAuthorship W3090227473A5056345051 @default.
• W3090227473 hasAuthorship W3090227473A5069532552 @default.
• W3090227473 hasAuthorship W3090227473A5080853241 @default.
• W3090227473 hasConcept C103697762 @default.
• W3090227473 hasConcept C111919701 @default.
• W3090227473 hasConcept C112930515 @default.
• W3090227473 hasConcept C116834253 @default.
• W3090227473 hasConcept C127413603 @default.
• W3090227473 hasConcept C150903083 @default.
• W3090227473 hasConcept C183696295 @default.
• W3090227473 hasConcept C2522767166 @default.
• W3090227473 hasConcept C2780035454 @default.
• W3090227473 hasConcept C41008148 @default.
• W3090227473 hasConcept C59822182 @default.
• W3090227473 hasConcept C60644358 @default.
• W3090227473 hasConcept C64903051 @default.
• W3090227473 hasConcept C70721500 @default.
• W3090227473 hasConcept C71924100 @default.
• W3090227473 hasConcept C74187038 @default.
• W3090227473 hasConcept C86803240 @default.
• W3090227473 hasConcept C98045186 @default.
• W3090227473 hasConcept C98274493 @default.
• W3090227473 hasConceptScore W3090227473C103697762 @default.
• W3090227473 hasConceptScore W3090227473C111919701 @default.
• W3090227473 hasConceptScore W3090227473C112930515 @default.
• W3090227473 hasConceptScore W3090227473C116834253 @default.

• next