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• W3090238887 endingPage "e9996" @default.
• W3090238887 startingPage "e9996" @default.
• W3090238887 abstract "Squamous cell lung carcinoma (LUSC) was closely associated with smoking which was known to have a distant immunosuppression effect. In this study, we aimed to explore the relationship between immune cells and clinical outcomes of LUSC patients with smoking history.The immune cell infiltration and RNA expression profiles of LUSC patients were collected from The Cancer Genome Atlas (TCGA). Then, the correlation between immune cell infiltration and clinical characteristics was explored. According to the level of immune cell infiltration, LUSC patients with smoking history were divided into high or low group to screen the differentially expressed lncRNAs and mRNAs. The prediction of target genes was performed by miRanda. Finally, the prognostic value of a certain signature was confirmed in an independent dataset.Higher abundance of tumor-infiltrating T follicular helper (Tfh) cells together with a lower abundance of resting memory CD4 T cells had been found in LUSC current reformed smokers for ≤15 years and current smoking patients. Moreover, Tfh cell infiltration was not only associated with better overall survival (OS) but also varied from different degrees of TNM stage. Low expression of lncRNA PWRN1 and its potential regulating genes DMRTB1, PIRT, APOBEC1, and ZPBP2 were associated with better OS. Combining PWRN1 and four regulating genes as a signature, patients with higher-level expression of the signature had shorter survival time in not only the TCGA but also in the GEO dataset.It was found that Tfh cells presented higher infiltration in LUSC current reformed smokers for ≤15 years and current smokers, while resting memory CD4 T cells had lower infiltration. The signature consisting of PWRN1 as well as its predicted targeted mRNAs was dysregulated in different levels of Tfh cell infiltration and might indicate patients' OS." @default.
• W3090238887 created "2020-10-08" @default.
• W3090238887 creator A5081130966 @default.
• W3090238887 creator A5083385862 @default.
• W3090238887 date "2020-10-05" @default.
• W3090238887 modified "2023-09-26" @default.
• W3090238887 title "Immune cell landscape analysis reveals prognostic immune cells and its potential mechanism in squamous cell lung carcinoma" @default.
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• W3090238887 doi "https://doi.org/10.7717/peerj.9996" @default.
• W3090238887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7543728" @default.
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• W3090238887 hasPublicationYear "2020" @default.
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