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- W3090278610 abstract "Denosumab is a receptor activator of nuclear factor kappa-Β ligand inhibitor, which suppresses the bone resorption process to preserve bone mass. It is usually recommended to postmenopausal women and men with high fracture risk. With the recent publication of the results from FREEDOM study and its extension, the long-term effect of denosumab in preventing fragility fractures has been put forward. This review aims at summarising the evidence of denosumab in reducing fracture risk and its safety derived from clinical studies. Most of the evidence are derived from FREEDOM trials up to 10 years of exposure. Denosumab is reported to prevent vertebral and non-vertebral fractures. It is also proven effective in Japanese women, patients with chronic kidney diseases and breast cancer patients receiving antineoplastic therapy. Denosumab discontinuation leads to high remodeling, loss of bone mineral density and increased fracture risk. These negative effects might be preventable by bisphosphonate treatment. The safety profile of denosumab is consistent with increased years of exposure. In conclusion, denosumab is a safe and effective option for reducing fracture risk among patients with osteoporosis." @default.
- W3090278610 created "2020-10-08" @default.
- W3090278610 creator A5004337432 @default.
- W3090278610 creator A5004770379 @default.
- W3090278610 creator A5085290256 @default.
- W3090278610 date "2020-10-01" @default.
- W3090278610 modified "2023-09-29" @default.
- W3090278610 title "<p>A Review on the Role of Denosumab in Fracture Prevention</p>" @default.
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- W3090278610 doi "https://doi.org/10.2147/dddt.s270829" @default.
- W3090278610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7534845" @default.
- W3090278610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33061307" @default.
- W3090278610 hasPublicationYear "2020" @default.
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