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- W3090281552 endingPage "102117" @default.
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- W3090281552 abstract "The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots ([email protected]) by a carbodiimide crosslinking reaction. The [email protected] were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The [email protected] could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared [email protected] might be a great drug nano-platform for cancer, particularly leukemia treatments." @default.
- W3090281552 created "2020-10-08" @default.
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- W3090281552 date "2021-02-01" @default.
- W3090281552 modified "2023-09-25" @default.
- W3090281552 title "Graphene quantum dots decorated with imatinib for leukemia treatment" @default.
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- W3090281552 doi "https://doi.org/10.1016/j.jddst.2020.102117" @default.
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