FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090282318> ?p ?o ?g. }

• W3090282318 endingPage "614" @default.
• W3090282318 startingPage "601" @default.
• W3090282318 abstract "CD4+ T lymphocytes are key mediators of tissue damage after ischemic stroke. However, their infiltration kinetics and interactions with other immune cells in the delayed phase of ischemia remain elusive. We hypothesized that CD4+ T cells facilitate delayed autoreactive B cell responses in the brain, which have been previously linked to post-stroke cognitive impairment (PSCI). Therefore, we treated myelin oligodendrocyte glycoprotein T cell receptor transgenic 2D2 mice of both sexes with anti-CD4 antibody following 60-minute middle cerebral artery occlusion and assessed lymphocyte infiltration for up to 72 days. Anti-CD4-treatment eliminated CD4+ T cells from the circulation and ischemic brain for 28 days and inhibited B cell infiltration into the brain, particularly in animals with large infarcts. Absence of CD4+ T cells did not influence infarct maturation or survival. Once the CD4+ population recovered in the periphery, both CD4+ T and B lymphocytes entered the infarct site forming follicle-like structures. Additionally, we provide further evidence for PSCI that could be attenuated by CD4 depletion. Our findings demonstrate that CD4+ T cells are essential in delayed B cell infiltration into the ischemic brain after stroke. Importantly, lymphocyte infiltration after stroke is a long-lasting process. As CD4 depletion improved cognitive functions in an experimental set-up, these findings set the stage to elaborate more specific immune modulating therapies in treating PSCI." @default.
• W3090282318 created "2020-10-08" @default.
• W3090282318 creator A5001602377 @default.
• W3090282318 creator A5001633612 @default.
• W3090282318 creator A5016591005 @default.
• W3090282318 creator A5033510051 @default.
• W3090282318 creator A5039526582 @default.
• W3090282318 creator A5063045829 @default.
• W3090282318 creator A5065638265 @default.
• W3090282318 creator A5069451422 @default.
• W3090282318 date "2021-01-01" @default.
• W3090282318 modified "2023-10-10" @default.
• W3090282318 title "CD4+ T cells promote delayed B cell responses in the ischemic brain after experimental stroke" @default.
• W3090282318 cites W1519171461 @default.
• W3090282318 cites W1905741083 @default.
• W3090282318 cites W1950515180 @default.
• W3090282318 cites W1968057097 @default.
• W3090282318 cites W1970341486 @default.
• W3090282318 cites W1972262922 @default.
• W3090282318 cites W1987643886 @default.
• W3090282318 cites W1988100193 @default.
• W3090282318 cites W1999235115 @default.
• W3090282318 cites W2001775594 @default.
• W3090282318 cites W2002842060 @default.
• W3090282318 cites W2008403719 @default.
• W3090282318 cites W2013448781 @default.
• W3090282318 cites W2023749167 @default.
• W3090282318 cites W2027279895 @default.
• W3090282318 cites W2029906813 @default.
• W3090282318 cites W2038473458 @default.
• W3090282318 cites W2044607507 @default.
• W3090282318 cites W2046637170 @default.
• W3090282318 cites W2049521887 @default.
• W3090282318 cites W2071002641 @default.
• W3090282318 cites W2071252381 @default.
• W3090282318 cites W2072633245 @default.
• W3090282318 cites W2083565083 @default.
• W3090282318 cites W2084049757 @default.
• W3090282318 cites W2084745603 @default.
• W3090282318 cites W2087484885 @default.
• W3090282318 cites W2089379946 @default.
• W3090282318 cites W2089725161 @default.
• W3090282318 cites W2098435173 @default.
• W3090282318 cites W2101662803 @default.
• W3090282318 cites W2112177186 @default.
• W3090282318 cites W2118818657 @default.
• W3090282318 cites W2124617804 @default.
• W3090282318 cites W2125683177 @default.
• W3090282318 cites W2136030857 @default.
• W3090282318 cites W2146428873 @default.
• W3090282318 cites W2155477484 @default.
• W3090282318 cites W2156751422 @default.
• W3090282318 cites W2160805048 @default.
• W3090282318 cites W2328326888 @default.
• W3090282318 cites W2336097215 @default.
• W3090282318 cites W2435894626 @default.
• W3090282318 cites W2483265513 @default.
• W3090282318 cites W2520386517 @default.
• W3090282318 cites W2531419784 @default.
• W3090282318 cites W2534752852 @default.
• W3090282318 cites W2576382126 @default.
• W3090282318 cites W2587953391 @default.
• W3090282318 cites W2593078109 @default.
• W3090282318 cites W2616130713 @default.
• W3090282318 cites W2742536940 @default.
• W3090282318 cites W2801299660 @default.
• W3090282318 cites W2900920718 @default.
• W3090282318 cites W3088745299 @default.
• W3090282318 doi "https://doi.org/10.1016/j.bbi.2020.09.029" @default.
• W3090282318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33002634" @default.
• W3090282318 hasPublicationYear "2021" @default.
• W3090282318 type Work @default.
• W3090282318 sameAs 3090282318 @default.
• W3090282318 citedByCount "22" @default.
• W3090282318 countsByYear W30902823182020 @default.
• W3090282318 countsByYear W30902823182021 @default.
• W3090282318 countsByYear W30902823182022 @default.
• W3090282318 countsByYear W30902823182023 @default.
• W3090282318 crossrefType "journal-article" @default.
• W3090282318 hasAuthorship W3090282318A5001602377 @default.
• W3090282318 hasAuthorship W3090282318A5001633612 @default.
• W3090282318 hasAuthorship W3090282318A5016591005 @default.
• W3090282318 hasAuthorship W3090282318A5033510051 @default.
• W3090282318 hasAuthorship W3090282318A5039526582 @default.
• W3090282318 hasAuthorship W3090282318A5063045829 @default.
• W3090282318 hasAuthorship W3090282318A5065638265 @default.
• W3090282318 hasAuthorship W3090282318A5069451422 @default.
• W3090282318 hasBestOaLocation W30902823181 @default.
• W3090282318 hasConcept C121332964 @default.
• W3090282318 hasConcept C126322002 @default.
• W3090282318 hasConcept C127413603 @default.
• W3090282318 hasConcept C134018914 @default.
• W3090282318 hasConcept C153400128 @default.
• W3090282318 hasConcept C169760540 @default.
• W3090282318 hasConcept C203014093 @default.
• W3090282318 hasConcept C2778486448 @default.
• W3090282318 hasConcept C2778609137 @default.
• W3090282318 hasConcept C2779357208 @default.

• next