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- W3090321192 abstract "Abstract Regulatory genes are often multifunctional and constrained, which results in evolutionary conservation. It is difficult to understand how a regulatory gene could be lost from one species’ genome when it is essential for viability in closely related species. The gene paired is a classic Drosophila pair-rule gene, required for formation of alternate body segments in diverse insect species. Surprisingly, paired was lost in mosquitoes without disrupting body patterning. Here, we demonstrate that a paired family member, gooseberry , has acquired paired -like expression in the malaria mosquito Anopheles stephensi . Anopheles-gooseberry CRISPR-Cas9 knock-out mutants display pair-rule phenotypes and alteration of target gene expression similar to what is seen in Drosophila and beetle paired mutants. Thus, paired was functionally replaced by the related gene, gooseberry , in mosquitoes. Our findings document a rare example of a functional replacement of an essential regulatory gene and provide a mechanistic explanation of how such loss can occur." @default.
- W3090321192 created "2020-10-08" @default.
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- W3090321192 date "2020-09-30" @default.
- W3090321192 modified "2023-10-16" @default.
- W3090321192 title "Regulatory gene function handoff allows essential gene loss in mosquitoes" @default.
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- W3090321192 doi "https://doi.org/10.1038/s42003-020-01203-w" @default.
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