Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090340635> ?p ?o ?g. }
- W3090340635 endingPage "13019" @default.
- W3090340635 startingPage "13010" @default.
- W3090340635 abstract "Abstract Long noncoding RNAs have key roles in glioma progression. However, the function and mechanisms of action of the long noncoding RNA, LINC00346 , in glioma remain unclear. In our study, we observed that LINC00346 levels were increased in glioma tissue samples, and according to Gene Expression Profiling Interactive Analysis, its levels were related to disease‐free survival and overall survival rates, suggesting that a high level of LINC00346 expression corresponds to a poor prognosis. We next confirmed the high levels of LINC00346 expression in glioma tissues and cell lines and showed that LINC00346 knockdown suppressed glioma cell proliferation, migration and invasion; promoted apoptosis; and delayed tumour growth. Moreover, the oncogenic function of LINC00346 may be explained, in part, by the down‐regulation of miR‐340‐5p and the de‐repression of ROCK1 . We showed that LINC00346 may function as a competing endogenous RNA of miR‐340‐5p , thereby de‐repressing ROCK1 . This study revealed a new regulatory network in glioma and identified potential therapeutic targets for this cancer." @default.
- W3090340635 created "2020-10-08" @default.
- W3090340635 creator A5014191118 @default.
- W3090340635 creator A5028517221 @default.
- W3090340635 creator A5042416671 @default.
- W3090340635 creator A5043128189 @default.
- W3090340635 creator A5046958871 @default.
- W3090340635 creator A5069544834 @default.
- W3090340635 creator A5072027446 @default.
- W3090340635 creator A5078120636 @default.
- W3090340635 creator A5085971774 @default.
- W3090340635 date "2020-09-29" @default.
- W3090340635 modified "2023-09-26" @default.
- W3090340635 title "Long noncoding RNA <i>LINC00346</i> promotes glioma cell migration, invasion and proliferation by up‐regulating ROCK1" @default.
- W3090340635 cites W1968711495 @default.
- W3090340635 cites W1970741980 @default.
- W3090340635 cites W1973462022 @default.
- W3090340635 cites W1975439559 @default.
- W3090340635 cites W1996281275 @default.
- W3090340635 cites W2073278656 @default.
- W3090340635 cites W2094295834 @default.
- W3090340635 cites W2100100194 @default.
- W3090340635 cites W2164049072 @default.
- W3090340635 cites W2190647258 @default.
- W3090340635 cites W2278083454 @default.
- W3090340635 cites W2593421239 @default.
- W3090340635 cites W2607129810 @default.
- W3090340635 cites W2750945356 @default.
- W3090340635 cites W2800031203 @default.
- W3090340635 cites W2913633759 @default.
- W3090340635 cites W2917349269 @default.
- W3090340635 cites W2917651758 @default.
- W3090340635 cites W2919642485 @default.
- W3090340635 cites W2942636487 @default.
- W3090340635 cites W2943861831 @default.
- W3090340635 cites W2944383857 @default.
- W3090340635 cites W2945040240 @default.
- W3090340635 cites W2947249015 @default.
- W3090340635 cites W2948005300 @default.
- W3090340635 cites W2948178326 @default.
- W3090340635 cites W2949862994 @default.
- W3090340635 cites W2950187230 @default.
- W3090340635 cites W2950216037 @default.
- W3090340635 cites W2950967139 @default.
- W3090340635 cites W2951498518 @default.
- W3090340635 cites W2957635805 @default.
- W3090340635 cites W2960714002 @default.
- W3090340635 cites W2964658374 @default.
- W3090340635 cites W2965128075 @default.
- W3090340635 cites W2966514809 @default.
- W3090340635 cites W2967725497 @default.
- W3090340635 cites W2968830168 @default.
- W3090340635 cites W2969726701 @default.
- W3090340635 cites W2970754665 @default.
- W3090340635 cites W2971934519 @default.
- W3090340635 cites W2972231100 @default.
- W3090340635 cites W2974607210 @default.
- W3090340635 cites W2988418310 @default.
- W3090340635 cites W3005597885 @default.
- W3090340635 cites W3007902813 @default.
- W3090340635 cites W3090340635 @default.
- W3090340635 doi "https://doi.org/10.1111/jcmm.15899" @default.
- W3090340635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7701529" @default.
- W3090340635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32996285" @default.
- W3090340635 hasPublicationYear "2020" @default.
- W3090340635 type Work @default.
- W3090340635 sameAs 3090340635 @default.
- W3090340635 citedByCount "7" @default.
- W3090340635 countsByYear W30903406352020 @default.
- W3090340635 countsByYear W30903406352021 @default.
- W3090340635 countsByYear W30903406352022 @default.
- W3090340635 crossrefType "journal-article" @default.
- W3090340635 hasAuthorship W3090340635A5014191118 @default.
- W3090340635 hasAuthorship W3090340635A5028517221 @default.
- W3090340635 hasAuthorship W3090340635A5042416671 @default.
- W3090340635 hasAuthorship W3090340635A5043128189 @default.
- W3090340635 hasAuthorship W3090340635A5046958871 @default.
- W3090340635 hasAuthorship W3090340635A5069544834 @default.
- W3090340635 hasAuthorship W3090340635A5072027446 @default.
- W3090340635 hasAuthorship W3090340635A5078120636 @default.
- W3090340635 hasAuthorship W3090340635A5085971774 @default.
- W3090340635 hasBestOaLocation W30903406351 @default.
- W3090340635 hasConcept C104317684 @default.
- W3090340635 hasConcept C133717845 @default.
- W3090340635 hasConcept C145059251 @default.
- W3090340635 hasConcept C150194340 @default.
- W3090340635 hasConcept C173396325 @default.
- W3090340635 hasConcept C186310378 @default.
- W3090340635 hasConcept C194993378 @default.
- W3090340635 hasConcept C2777093181 @default.
- W3090340635 hasConcept C2778227246 @default.
- W3090340635 hasConcept C502942594 @default.
- W3090340635 hasConcept C54355233 @default.
- W3090340635 hasConcept C60365752 @default.
- W3090340635 hasConcept C62112901 @default.
- W3090340635 hasConcept C62203573 @default.
- W3090340635 hasConcept C62478195 @default.
- W3090340635 hasConcept C67705224 @default.