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• W3090345986 abstract "<br>The incidence of nephrolithiasis is increasing worldwide. Understanding how gut microbiome influences oxalate homeostasis has the potential to offer new strategies to prevent nephrolithiasis. The literature was reviewed to gather the evidence on the association between gut microbiome, hyperoxaluria and nephrolithiasis, and to identify the therapeutic interventions focused on the gut microbiome that could decrease hyperoxaluria and prevent nephrolithiasis. Gut microbiome is constituted by a plethora of microbiota including<i> Oxalobacter formigenes </i>(Oxf) and lactobacilli. Oxf can degrade dietary oxalate and induce enteral oxalate secretion. Animal studies suggested an association between oral <i>Oxf</i> supplementation and a decrease in hyperoxaluria. However, human studies have showed inconsistent results. Oral supplementation of lactobacilli did not show benefit in decreasing the hyperoxaluria. Antibiotic exposure, by affecting the gut microbiome, has been associated with an increase in nephrolithiasis. <i>In vivo</i> studies suggest fecal transplantation as a potential treatment option for reducing nephrolithiasis, but needs further evaluation in clinical studies. The current evidence suggests an association between gut microbiome and nephrolithiasis. However, the strategies focused on modulating gut microbiome for decreasing hyperoxaluria and preventing nephrolithiasis need further research. Judicious use of antibiotics in those predisposed to nephrolithiasis offers a preventative strategy for decreasing nephrolithiasis.<br>" @default.
• W3090345986 created "2020-10-08" @default.
• W3090345986 creator A5029655672 @default.
• W3090345986 creator A5038529776 @default.
• W3090345986 creator A5068834577 @default.
• W3090345986 creator A5081126623 @default.
• W3090345986 date "2020-01-01" @default.
• W3090345986 modified "2023-09-27" @default.
• W3090345986 title "Current update and future directions on gut microbiome and nephrolithiasis" @default.
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• W3090345986 doi "https://doi.org/10.4103/iju.iju_20_20" @default.
• W3090345986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7759161" @default.
• W3090345986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33376261" @default.
• W3090345986 hasPublicationYear "2020" @default.
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