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• W3090352242 abstract "Abstract Background A lung transplant is the last resort treatment for many patients with advanced lung disease. The majority of donated lungs come from donors following brain death (BD). The endothelin axis is upregulated in the blood and lung of the donor after BD resulting in systemic inflammation, lung damage and poor lung graft outcomes in the recipient. Tezosentan (endothelin receptor blocker) improves the pulmonary haemodynamic profile; however, it induces adverse effects on other organs at high doses. Application of ex vivo lung perfusion (EVLP) allows the development of organ-specific hormone resuscitation, to maximise and optimise the donor pool. Therefore, we investigate whether the combination of EVLP and tezosentan administration could improve the quality of donor lungs in a clinically relevant 6-h ovine model of brain stem death (BSD). Methods After 6 h of BSD, lungs obtained from 12 sheep were divided into two groups, control and tezosentan-treated group, and cannulated for EVLP. The lungs were monitored for 6 h and lung perfusate and tissue samples were processed and analysed. Blood gas variables were measured in perfusate samples as well as total proteins and pro-inflammatory biomarkers, IL-6 and IL-8. Lung tissues were collected at the end of EVLP experiments for histology analysis and wet-dry weight ratio (a measure of oedema). Results Our results showed a significant improvement in gas exchange [elevated partial pressure of oxygen (P = 0.02) and reduced partial pressure of carbon dioxide (P = 0.03)] in tezosentan-treated lungs compared to controls. However, the lungs hematoxylin–eosin staining histology results showed minimum lung injuries and there was no difference between both control and tezosentan-treated lungs. Similarly, IL-6 and IL-8 levels in lung perfusate showed no difference between control and tezosentan-treated lungs throughout the EVLP. Histological and tissue analysis showed a non-significant reduction in wet/dry weight ratio in tezosentan-treated lung tissues (P = 0.09) when compared to control. Conclusions These data indicate that administration of tezosentan could improve pulmonary gas exchange during EVLP." @default.
• W3090352242 created "2020-10-08" @default.
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• W3090352242 date "2020-10-02" @default.
• W3090352242 modified "2023-10-17" @default.
• W3090352242 title "Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system" @default.
• W3090352242 cites W1524621166 @default.
• W3090352242 cites W1664923329 @default.
• W3090352242 cites W1680472002 @default.
• W3090352242 cites W1919855383 @default.
• W3090352242 cites W1963525654 @default.
• W3090352242 cites W1964243071 @default.
• W3090352242 cites W1969530790 @default.
• W3090352242 cites W1977853109 @default.
• W3090352242 cites W1978253604 @default.
• W3090352242 cites W1990823740 @default.
• W3090352242 cites W1996705472 @default.
• W3090352242 cites W2001252757 @default.
• W3090352242 cites W2004441714 @default.
• W3090352242 cites W2005940382 @default.
• W3090352242 cites W2008349036 @default.
• W3090352242 cites W2009493508 @default.
• W3090352242 cites W2027247941 @default.
• W3090352242 cites W2027747307 @default.
• W3090352242 cites W2029299919 @default.
• W3090352242 cites W2029611997 @default.
• W3090352242 cites W2037000479 @default.
• W3090352242 cites W2037460026 @default.
• W3090352242 cites W2038975479 @default.
• W3090352242 cites W2039558665 @default.
• W3090352242 cites W2042141901 @default.
• W3090352242 cites W2048646176 @default.
• W3090352242 cites W2050596342 @default.
• W3090352242 cites W2055617694 @default.
• W3090352242 cites W2056805613 @default.
• W3090352242 cites W2059074793 @default.
• W3090352242 cites W2059386118 @default.
• W3090352242 cites W2063051980 @default.
• W3090352242 cites W2069003041 @default.
• W3090352242 cites W2073912003 @default.
• W3090352242 cites W2081120686 @default.
• W3090352242 cites W2082089368 @default.
• W3090352242 cites W2084687436 @default.
• W3090352242 cites W2086877710 @default.
• W3090352242 cites W2101563821 @default.
• W3090352242 cites W2108519539 @default.
• W3090352242 cites W2108875876 @default.
• W3090352242 cites W2120554320 @default.
• W3090352242 cites W2127455984 @default.
• W3090352242 cites W2130031747 @default.
• W3090352242 cites W2132669112 @default.
• W3090352242 cites W2145410423 @default.
• W3090352242 cites W2152506084 @default.
• W3090352242 cites W2159844139 @default.
• W3090352242 cites W2164443547 @default.
• W3090352242 cites W2167412989 @default.
• W3090352242 cites W2167527394 @default.
• W3090352242 cites W2169631816 @default.
• W3090352242 cites W2177377466 @default.
• W3090352242 cites W2199804889 @default.
• W3090352242 cites W2218724812 @default.
• W3090352242 cites W2223594321 @default.
• W3090352242 cites W2223817465 @default.
• W3090352242 cites W2289112501 @default.
• W3090352242 cites W2317622395 @default.
• W3090352242 cites W2318774309 @default.
• W3090352242 cites W2347111551 @default.
• W3090352242 cites W2518225242 @default.
• W3090352242 cites W2521772820 @default.
• W3090352242 cites W2562239512 @default.
• W3090352242 cites W2612103588 @default.
• W3090352242 cites W2886579740 @default.
• W3090352242 cites W2908919389 @default.
• W3090352242 doi "https://doi.org/10.1186/s12929-020-00690-7" @default.

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