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- W3090355613 abstract "When humans domesticated animals, some adapted genetically to digest milk into adulthood (lactase persistence). The gut microbiomes of people with lactase-persistent genotypes (AA or AG) differ from those with lactase-nonpersistent genotypes (GG) by containing fewer bacteria belonging to the bifidobacteria, a group which contains beneficial species. Here, we asked if the gut microbiomes of adults with GG and AA/AG genotypes differ in the species of bifidobacteria present. In particular, we used a novel technique which allowed us to compare bifidobacteria in adults at the strain level, without the traditional need for culturing. Our results show that the GG genotype enhances the abundance of bifidobacteria regardless of species. We also noted that a person’s specific strains are recoverable several years later, and twins can share the same ones. Given that bifidobacteria are inherited from mother to child, strain stability over time in adulthood suggests long-term, multigenerational inheritance." @default.
- W3090355613 created "2020-10-08" @default.
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- W3090355613 date "2020-10-27" @default.
- W3090355613 modified "2023-10-16" @default.
- W3090355613 title "Strain-Level Analysis of <i>Bifidobacterium</i> spp. from Gut Microbiomes of Adults with Differing Lactase Persistence Genotypes" @default.
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- W3090355613 doi "https://doi.org/10.1128/msystems.00911-20" @default.
- W3090355613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7527142" @default.
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