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- W3090392919 abstract "Madrid has been the epicenter of the SARS-CoV2 pandemic in Spain. We analyzed the experience at our hospital with SARS-CoV2 infection and cancer patients (p). We analyzed our experience from March 1 to April 30 at the Puerta de Hierro University Hospital in Madrid. Diagnosis of SARS-CoV2 infection was made by RT-PCR, suspected cases not confirmed were excluded. Overall in-hospital mortality cancer p with COVID-19 was 15.2% (95%CI, 6.3; 5.2), similar to 12.7% (95%CI,11.1;4.4) with p=0.615 of the global COVID-19 hospitalised population and greater than that of patients admitted without SARS-CoV-2 infection during the same period 4.3% (95%CI; 3.6;5.2) p<0.001. Among 653 patients receiving active cancer therapy during this period, 24 (3.7%) developed COVID-19 and required admission, 4.2% of were receiving chemotherapy, 9.5% immunotherapy and 2.1% targeted therapies. Lung and breast cancer were the most frequent (26.1%), followed by colorectal (19.6%) and breast cancer. No significant differences due to the cancer treatment received were observed. Mortality in lung cancer patients was the highest (25%). The univariate analysis (between p who developed serious event vs. those who did not), showed that higher Brescia, CURB-65 scale, lactate dehydrogenase (LDH) or C-reactive protein (CRP) levels at admission, the greater risk of developing severe complications (p<0.05)Table: 1733PVARIABLEOTHER CANCER N=34 (%)LUNG CANCER N=12 (%)Male52.950Age mean63.963.5Active Smoking016.7Ex-smokers35.350COMORBIDITIESCoronary heart disease8.816.7Hypertension35.341.7COPD8.816.7Dyslipidemia23.525STAGEIV52.950SYMPTOMSpNeutropenia6.101.0Cough67.641.7.17Temperature37.137.3.36Dyspnoea4791.7.007Diarrhea8.88.31.0Lymphopenia68.736.4.08PROGNOSTIC CRITERIAIL6.41D-DIMER0.9 (0.6; 2.2)0.9 (0.5; 2.7).57PCR107.7.44LDH266 (207; 326)290 (238; 352).19FERRITIN562 (358; 933)1111 (392; 2672).15CHARLSON INDEX*8 (6; 9)8 (6; 9).80CURB65 SCALE **.31BRESCIA SCALE.17 Open table in a new tab . Patients with cancer, especially lung cancer, and SARS-CoV2 infection have a worse overall prognosis than the general population. Objective parameters such as LDH, CRP at admission, Brescia index or CURB-65 should alert us to a more serious evolution and suggest early an early intensive care unit (ICU) admission." @default.
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- W3090392919 date "2020-09-01" @default.
- W3090392919 modified "2023-09-28" @default.
- W3090392919 title "1733P Real-world data: Cancer and SARS-CoV-2 infection" @default.
- W3090392919 doi "https://doi.org/10.1016/j.annonc.2020.08.1797" @default.
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