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- W3090395497 abstract "Significance Millions of people have been exposed to asbestos and are at increased risk of developing mesothelioma, an aggressive malignancy resistant to current therapies. Here, we elucidate critical steps in asbestos carcinogenesis: asbestos induces the release of high mobility group box 1 that triggers autophagy. Autophagy activation constitutes a key biological process that allows some mesothelial cells to survive asbestos cytotoxicity and consequently increases the fraction of DNA-damaged human mesothelial cells susceptible to malignant transformation. We found that the inhibition of autophagy using either chloroquine or the antidepressant drug desmethylclomipramine increased asbestos-induced cell death and reduced asbestos-mediated cell transformation. Our data suggest that these Food and Drug Administration-approved drugs might be repurposed to protect high-risk asbestos-exposed individuals from developing mesothelioma." @default.
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- W3090395497 date "2020-09-30" @default.
- W3090395497 modified "2023-10-14" @default.
- W3090395497 title "Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy" @default.
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- W3090395497 doi "https://doi.org/10.1073/pnas.2007622117" @default.
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