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• W3090397375 abstract "Abstract Objectives Articular cartilage plays a vital role in bearing and buffering. Injured cartilage and subchondral bone repair is a crucial challenge in cartilage tissue engineering due to the peculiar structure of osteochondral unit and the requirement of osteogenic/chondrogenic bi‐directional differentiation. Based on the bionics principle, a nanotextured silk fibroin (SF)‐chondroitin sulphate (CS)/hydroxyapatite (HAp) nanowire tough bilayer structure was prepared for osteochondral repair. Methods The SF‐CS/HAp membrane was constructed by alcohol‐induced β‐sheet formation serving as the physical crosslink. Its osteochondral repairing capacity was evaluated by culturing bone marrow mesenchymal stem cells (BMSCs) in vitro and constructing a rat osteochondral defect model in vivo. Results The bilayer SF‐CS/HAp membrane with satisfactory mechanical properties similar to natural cartilage imitated the natural osteochondral unit structural layers and exerted the function of bearing and buffering timely after in vivo implantation. SF‐CS layer upregulated the expression of chondrogenesis‐related genes of BMSCs by surface nanotopography and sustained release CS. Meanwhile, nanotextured HAp layer assembled with nanowire endowed the membrane with an osteogenic differentiation tendency for BMSCs. In vivo results proved that the biomimetic bilayer structure dramatically promoted new cartilage formation and subchondral bone remodelling for osteochondral defect model after implantation. Conclusions The SF‐CS/HAp biomimetic bilayer membrane provides a promising strategy for precise osteochondral repair." @default.
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• W3090397375 date "2020-10-01" @default.
• W3090397375 modified "2023-10-16" @default.
• W3090397375 title "Nanotextured silk fibroin/hydroxyapatite biomimetic bilayer tough structure regulated osteogenic/chondrogenic differentiation of mesenchymal stem cells for osteochondral repair" @default.
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• W3090397375 doi "https://doi.org/10.1111/cpr.12917" @default.
• W3090397375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7653257" @default.
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• W3090397375 hasPublicationYear "2020" @default.
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