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- W3090429615 abstract "Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration (IVDD) is one of the leading causes of LBP. However, the pathogenesis of IVD-related LBP is still controversial, and the treatment means are also insufficient to date. In recent decades, the role of structure and function changes of sensory nervous system in the induction and the maintenance of LBP is drawing more and more attention. With the progress of IVDD, IVD cell exhaustion and extracellular matrix degradation result in IVD structural damage, while neovascularization, innervation and inflammatory activation further deteriorate the microenvironment of IVD. New nerve ingrowth into degenerated IVD amplifies the impacts of IVD-derived nociceptive molecules on sensory endings. Moreover, IVDD is usually accompanied with disc herniation, which could injure and inflame affected nerves. Under mechanical and pro-inflammatory stimulation, the pain-transmitting pathway exhibits a sensitized function state and ultimately leads to LBP. Hence, relevant pathogenic factors, such as neurotrophins, ion channels, inflammatory factors, etc., are supposed to serve as promising therapeutic targets for LBP. The purpose of this review is to comprehensively summarize the current evidence on 1) the pathological changes of sensory nervous system during IVDD and their association with LBP, and 2) potential therapeutic strategies for LBP targeting relevant pathogenic factors." @default.
- W3090429615 created "2020-10-08" @default.
- W3090429615 creator A5007581386 @default.
- W3090429615 creator A5021577413 @default.
- W3090429615 creator A5022913770 @default.
- W3090429615 creator A5031874800 @default.
- W3090429615 creator A5067040936 @default.
- W3090429615 creator A5077971854 @default.
- W3090429615 creator A5080294582 @default.
- W3090429615 date "2021-01-01" @default.
- W3090429615 modified "2023-09-29" @default.
- W3090429615 title "The role of structure and function changes of sensory nervous system in intervertebral disc-related low back pain" @default.
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