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- W3090445950 abstract "Background/Aim: Accumulating evidence shows that caspase-8 (Cas-8) rs3834129 genotypes determine susceptibility to various cancers, but their association with nasopharyngeal carcinoma (NPC) has not been examined. We aimed at investigating the association of Cas-8 rs3834129 with NPC risk. Materials and Methods: Cas-8 rs3834129 genotypes and their associations with NPC risk were investigated among 176 NPC patients and 352 non-cancer subjects by the PCR-RFLP method. Additionally, the interaction of Cas-8 rs3834129 genotypes with smoking was examined. Results: The II, ID and DD frequencies were 56.8, 36.9 and 6.3% among NPC patients and 54.8, 38.1 and 7.1% among control subjects (p<sub>trend</sub>=0.8830). Allelic frequency distribution analysis also indicated that the D allele is not a risk factor for NPC (p=0.6183). There was no interaction between Cas-8 rs3834129 and smoking and NPC risk (p=0.8305). Conclusion: Cas-8 rs3834129 genotypes play a minor role in the risk for NPC." @default.
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- W3090445950 date "2020-09-28" @default.
- W3090445950 modified "2023-10-18" @default.
- W3090445950 title "Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan" @default.
- W3090445950 doi "https://doi.org/10.21873/anticanres.14562" @default.
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