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- W3090495129 abstract "The prognosis of metastatic clear cell renal cell carcinoma (mccRCC) has changed dramatically over the years with the emergence of immune checkpoint inhibitors (ICI) used alone, or in combination with another ICI, or with vascular endothelial growth factor receptor tyrosine kinase inhibitor. Although major response rates have been observed with ICI, many patients do not respond, reflecting primary resistance, and durable responses remain exceptional, reflecting secondary resistance. Factors contributing to primary and acquired resistance are manifold, including patient-intrinsic factors, tumor cell-intrinsic factors and factors associated with the tumoral microenvironment (TME). While some mechanisms of resistance are common to several tumor types, others are specific to mccRCC. Predictive biomarkers and alternative strategies are needed to overcome this resistance. This review provides an overview of the major ICI resistance mechanisms, highlights the potential of the TME to induce resistance to ICI, and discusses the predictive biomarkers available to guide therapeutic choice." @default.
- W3090495129 created "2020-10-08" @default.
- W3090495129 creator A5001863885 @default.
- W3090495129 creator A5025502682 @default.
- W3090495129 creator A5047019507 @default.
- W3090495129 creator A5050352004 @default.
- W3090495129 creator A5086664068 @default.
- W3090495129 creator A5090587408 @default.
- W3090495129 date "2020-01-01" @default.
- W3090495129 modified "2023-10-14" @default.
- W3090495129 title "https://cdrjournal.com/article/view/3531" @default.
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