Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090513376> ?p ?o ?g. }
- W3090513376 endingPage "108208" @default.
- W3090513376 startingPage "108208" @default.
- W3090513376 abstract "ATP11C, a plasma membrane phospholipid flippase, maintains the asymmetric distribution of phosphatidylserine accumulated in the inner leaflet. Caspase-dependent inactivation of ATP11C is essential for an apoptotic “eat me” signal, phosphatidylserine exposure, which prompts phagocytes to engulf cells. We show six cryo-EM structures of ATP11C at 3.0–4.0 Å resolution in five different states of the transport cycle. A structural comparison reveals phosphorylation-driven domain movements coupled with phospholipid binding. Three structures of phospholipid-bound states visualize phospholipid translocation accompanied by the rearrangement of transmembrane helices and an unwound portion at the occlusion site, and thus they detail the basis for head group recognition and the locality of the protein-bound acyl chains in transmembrane grooves. Invariant Lys880 and the surrounding hydrogen-bond network serve as a pivot point for helix bending and precise P domain inclination, which is crucial for dephosphorylation. The structures detail key features of phospholipid translocation by ATP11C, and a common basic mechanism for flippases is emerging." @default.
- W3090513376 created "2020-10-08" @default.
- W3090513376 creator A5008483997 @default.
- W3090513376 creator A5016192410 @default.
- W3090513376 creator A5018192479 @default.
- W3090513376 creator A5019961334 @default.
- W3090513376 creator A5022487976 @default.
- W3090513376 creator A5026973775 @default.
- W3090513376 creator A5056035877 @default.
- W3090513376 date "2020-09-01" @default.
- W3090513376 modified "2023-10-14" @default.
- W3090513376 title "Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM" @default.
- W3090513376 cites W1871390418 @default.
- W3090513376 cites W1966112781 @default.
- W3090513376 cites W1968188734 @default.
- W3090513376 cites W1983398269 @default.
- W3090513376 cites W1988992275 @default.
- W3090513376 cites W1990708284 @default.
- W3090513376 cites W1992138517 @default.
- W3090513376 cites W2006505293 @default.
- W3090513376 cites W2006831581 @default.
- W3090513376 cites W2017599638 @default.
- W3090513376 cites W2029717093 @default.
- W3090513376 cites W2036695009 @default.
- W3090513376 cites W2037732373 @default.
- W3090513376 cites W2038479528 @default.
- W3090513376 cites W2049948334 @default.
- W3090513376 cites W2059496396 @default.
- W3090513376 cites W2061108756 @default.
- W3090513376 cites W2065754127 @default.
- W3090513376 cites W2072718785 @default.
- W3090513376 cites W2093524221 @default.
- W3090513376 cites W2094218961 @default.
- W3090513376 cites W2098550162 @default.
- W3090513376 cites W2099133435 @default.
- W3090513376 cites W2104803435 @default.
- W3090513376 cites W2108713843 @default.
- W3090513376 cites W2109503333 @default.
- W3090513376 cites W2113256330 @default.
- W3090513376 cites W2127596679 @default.
- W3090513376 cites W2129723413 @default.
- W3090513376 cites W2132629607 @default.
- W3090513376 cites W2142161929 @default.
- W3090513376 cites W2144081223 @default.
- W3090513376 cites W2144887020 @default.
- W3090513376 cites W2152562710 @default.
- W3090513376 cites W2153331570 @default.
- W3090513376 cites W2165555639 @default.
- W3090513376 cites W2166840071 @default.
- W3090513376 cites W2180229411 @default.
- W3090513376 cites W2224482007 @default.
- W3090513376 cites W2460383191 @default.
- W3090513376 cites W2475810823 @default.
- W3090513376 cites W2593511418 @default.
- W3090513376 cites W2734356283 @default.
- W3090513376 cites W2736688032 @default.
- W3090513376 cites W2795294833 @default.
- W3090513376 cites W2887001097 @default.
- W3090513376 cites W2899714098 @default.
- W3090513376 cites W2902712591 @default.
- W3090513376 cites W2911295821 @default.
- W3090513376 cites W2953320394 @default.
- W3090513376 cites W2953771712 @default.
- W3090513376 cites W2969027959 @default.
- W3090513376 cites W2969084200 @default.
- W3090513376 cites W2995693483 @default.
- W3090513376 cites W2998678926 @default.
- W3090513376 cites W3029168653 @default.
- W3090513376 doi "https://doi.org/10.1016/j.celrep.2020.108208" @default.
- W3090513376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32997992" @default.
- W3090513376 hasPublicationYear "2020" @default.
- W3090513376 type Work @default.
- W3090513376 sameAs 3090513376 @default.
- W3090513376 citedByCount "47" @default.
- W3090513376 countsByYear W30905133762020 @default.
- W3090513376 countsByYear W30905133762021 @default.
- W3090513376 countsByYear W30905133762022 @default.
- W3090513376 countsByYear W30905133762023 @default.
- W3090513376 crossrefType "journal-article" @default.
- W3090513376 hasAuthorship W3090513376A5008483997 @default.
- W3090513376 hasAuthorship W3090513376A5016192410 @default.
- W3090513376 hasAuthorship W3090513376A5018192479 @default.
- W3090513376 hasAuthorship W3090513376A5019961334 @default.
- W3090513376 hasAuthorship W3090513376A5022487976 @default.
- W3090513376 hasAuthorship W3090513376A5026973775 @default.
- W3090513376 hasAuthorship W3090513376A5056035877 @default.
- W3090513376 hasBestOaLocation W30905133761 @default.
- W3090513376 hasConcept C118892022 @default.
- W3090513376 hasConcept C12554922 @default.
- W3090513376 hasConcept C170493617 @default.
- W3090513376 hasConcept C185592680 @default.
- W3090513376 hasConcept C188810444 @default.
- W3090513376 hasConcept C24530287 @default.
- W3090513376 hasConcept C2777019660 @default.
- W3090513376 hasConcept C2778918659 @default.
- W3090513376 hasConcept C2779637612 @default.
- W3090513376 hasConcept C41625074 @default.
- W3090513376 hasConcept C55493867 @default.