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- W3090548802 abstract "Significance Complex transcription factor networks regulate the development, maturation, and lineage commitment of dendritic cell (DC) subsets. Here, we demonstrate a previously unexpected role of the transcription factor C/EBPβ in murine DC maturation and immunogenic functionality under homeostatic and lymphoma-transformed conditions. Regulated expression of functional C/EBPβ isoforms enables a controlled maturation of DCs. In contrast, the presence of lymphoma cells leads to an up-regulation of C/EBPβ in DCs which transforms them into an immature and protumorigenic subtype. This study also shows that inhibition of the C/EBPβ/mTOR signaling axis abrogates the protumorigenic function of human DCs, suggesting that inhibitors regulating C/EBPβ activity can be used for blocking tumor-promoting functions of DCs in the treatment of hematological neoplasms." @default.
- W3090548802 created "2020-10-08" @default.
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- W3090548802 date "2020-10-05" @default.
- W3090548802 modified "2023-10-16" @default.
- W3090548802 title "The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions" @default.
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- W3090548802 doi "https://doi.org/10.1073/pnas.2008883117" @default.
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