Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090576304> ?p ?o ?g. }
- W3090576304 abstract "Abstract The energetic demands of a cell are believed to increase during mitosis, but the rates of ATP synthesis and consumption during mitosis have not been quantified. Here, we monitor mitochondrial membrane potential of single lymphocytic leukemia cells and demonstrate that mitochondria hyperpolarize from the G2/M transition until the metaphase-anaphase transition. This hyperpolarization was dependent on cyclin-dependent kinase 1 (CDK1) activity. By using an electrical circuit model of mitochondria, we quantify mitochondrial ATP synthesis rates in mitosis from the single-cell time-dynamics of mitochondrial membrane potential. We find that mitochondrial ATP synthesis decreases by approximately 50% during early mitosis and increases back to G2 levels during cytokinesis. Consistently, ATP levels and ATP synthesis are lower in mitosis than in G2 in synchronized cell populations. Overall, our results provide insights into mitotic bioenergetics and suggest that cell division is not a highly energy demanding process." @default.
- W3090576304 created "2020-10-08" @default.
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- W3090576304 date "2020-10-05" @default.
- W3090576304 modified "2023-10-16" @default.
- W3090576304 title "Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division" @default.
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- W3090576304 doi "https://doi.org/10.1038/s41467-020-18769-y" @default.
- W3090576304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7536222" @default.
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- W3090576304 hasPublicationYear "2020" @default.
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