FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090585870> ?p ?o ?g. }

• W3090585870 abstract "Background Thermal ablative therapies, such as microwave ablation (MWA) or radiofrequency ablation (RFA), are standard treatments for HCC. In addition to the local tumor destruction, abscopal effects (a reduction of a tumor mass in areas that were not included in the thermal ablation) could be observed. These systemic effects may be mediated by anti-tumor immune response, which has been described for RFA. MWA is rapidly replacing RFA, but systemic immunostimulatory effects of MWA treatment have been poorly studied. Materials and Methods Patients receiving MWA for localized HCC were included in this study. Effects of MWA on peripheral blood mononuclear cells (PBMC) of HCC patients treated with MWA were analyzed by multicolor flow cytometry. Tumor-specific immune responses against 7 shared tumor antigens were analyzed using peptide pools in 3-color Fluorospot assays (Interferon-y/Interleukin-5/Interleukin-10). The impact of type, density and localization of tumor-infiltrating lymphocytes was assessed by immunohistochemistry (IHC) of CD3, CD4, CD8, FoxP3, CD38 and CD20 and digital image analyses (Immunoscore) of tumor specimens in an additional cohort of patients who received combined surgical resection and thermal ablation. Results While comprehensive flow cytometric analyses in sequential samples (day 0, 7 and 90) of a prospective patient cohort (n=23) demonstrated only moderate effects of MWA on circulating immune cell subsets, Fluorospot analyses revealed de novo or enhanced tumor-specific immune responses in 30% of these patients. This anti-tumor immune response was related to tumor control. Interferon-y and Interleukin-5 T cell responses against cancer testis antigens were more frequent in patients with a long-time remission (>12 months) after MWA (7/16) compared to patients suffering from an early relapse (0/13 patients). Presence of tumor-specific T cell response (Interferon-y and/or Interleukin-5) was associated to longer progression-free survival (15.0 vs. 10.0 months). Immunohistochemical analyses of resected tumor samples revealed that a high T cell infiltration in a second tumor lesion at the time of thermal ablation was associated with superior disease-free survival (37.4 vs. 13.1 months). Conclusions Our data demonstrates remarkable immune-related effects of MWA in HCC patients. This study and provides additional evidence for a combination of thermal ablation and immunotherapy in this challenging disease. Funding ‘Koeln Fortune’ and ‘CAP-CMMC’ local research grant (to P.G. and H.A.S.) supported our research. Disclosure Information E. Staib: None. K. Leuchte: None. M. Thelen: None. P. Gödel: None. A. Lechner: None. P. Zentis: None. M. Garcia-Marquez: None. D. Waldschmidt: None. R.R. Datta: None. R. Wahba: None. C. Wybranski: None. T. Zander: None. A. Quaas: None. U. Drebber: None. D.L. Stippel: None. C. Bruns: None. K. Wennhold: None. M. von Bergwelt-Baildon: None. H.A. Schlösser: None." @default.
• W3090585870 created "2020-10-08" @default.
• W3090585870 creator A5002419333 @default.
• W3090585870 creator A5002855110 @default.
• W3090585870 creator A5005102787 @default.
• W3090585870 creator A5007639601 @default.
• W3090585870 creator A5017861385 @default.
• W3090585870 creator A5021625542 @default.
• W3090585870 creator A5027382992 @default.
• W3090585870 creator A5034455397 @default.
• W3090585870 creator A5036710220 @default.
• W3090585870 creator A5043050716 @default.
• W3090585870 creator A5045953059 @default.
• W3090585870 creator A5048356727 @default.
• W3090585870 creator A5063018597 @default.
• W3090585870 creator A5063052168 @default.
• W3090585870 creator A5064861498 @default.
• W3090585870 creator A5067752154 @default.
• W3090585870 creator A5075191891 @default.
• W3090585870 creator A5086028947 @default.
• W3090585870 creator A5089927530 @default.
• W3090585870 date "2020-10-01" @default.
• W3090585870 modified "2023-09-26" @default.
• W3090585870 title "P02.03 Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma" @default.
• W3090585870 doi "https://doi.org/10.1136/jitc-2020-itoc7.39" @default.
• W3090585870 hasPublicationYear "2020" @default.
• W3090585870 type Work @default.
• W3090585870 sameAs 3090585870 @default.
• W3090585870 citedByCount "0" @default.
• W3090585870 crossrefType "journal-article" @default.
• W3090585870 hasAuthorship W3090585870A5002419333 @default.
• W3090585870 hasAuthorship W3090585870A5002855110 @default.
• W3090585870 hasAuthorship W3090585870A5005102787 @default.
• W3090585870 hasAuthorship W3090585870A5007639601 @default.
• W3090585870 hasAuthorship W3090585870A5017861385 @default.
• W3090585870 hasAuthorship W3090585870A5021625542 @default.
• W3090585870 hasAuthorship W3090585870A5027382992 @default.
• W3090585870 hasAuthorship W3090585870A5034455397 @default.
• W3090585870 hasAuthorship W3090585870A5036710220 @default.
• W3090585870 hasAuthorship W3090585870A5043050716 @default.
• W3090585870 hasAuthorship W3090585870A5045953059 @default.
• W3090585870 hasAuthorship W3090585870A5048356727 @default.
• W3090585870 hasAuthorship W3090585870A5063018597 @default.
• W3090585870 hasAuthorship W3090585870A5063052168 @default.
• W3090585870 hasAuthorship W3090585870A5064861498 @default.
• W3090585870 hasAuthorship W3090585870A5067752154 @default.
• W3090585870 hasAuthorship W3090585870A5075191891 @default.
• W3090585870 hasAuthorship W3090585870A5086028947 @default.
• W3090585870 hasAuthorship W3090585870A5089927530 @default.
• W3090585870 hasBestOaLocation W30905858701 @default.
• W3090585870 hasConcept C126322002 @default.
• W3090585870 hasConcept C142724271 @default.
• W3090585870 hasConcept C143998085 @default.
• W3090585870 hasConcept C147483822 @default.
• W3090585870 hasConcept C167672396 @default.
• W3090585870 hasConcept C203014093 @default.
• W3090585870 hasConcept C2777701055 @default.
• W3090585870 hasConcept C2778014663 @default.
• W3090585870 hasConcept C2778019345 @default.
• W3090585870 hasConcept C2778326572 @default.
• W3090585870 hasConcept C2778902805 @default.
• W3090585870 hasConcept C2779727006 @default.
• W3090585870 hasConcept C2781274730 @default.
• W3090585870 hasConcept C502942594 @default.
• W3090585870 hasConcept C553184892 @default.
• W3090585870 hasConcept C71924100 @default.
• W3090585870 hasConcept C8891405 @default.
• W3090585870 hasConceptScore W3090585870C126322002 @default.
• W3090585870 hasConceptScore W3090585870C142724271 @default.
• W3090585870 hasConceptScore W3090585870C143998085 @default.
• W3090585870 hasConceptScore W3090585870C147483822 @default.
• W3090585870 hasConceptScore W3090585870C167672396 @default.
• W3090585870 hasConceptScore W3090585870C203014093 @default.
• W3090585870 hasConceptScore W3090585870C2777701055 @default.
• W3090585870 hasConceptScore W3090585870C2778014663 @default.
• W3090585870 hasConceptScore W3090585870C2778019345 @default.
• W3090585870 hasConceptScore W3090585870C2778326572 @default.
• W3090585870 hasConceptScore W3090585870C2778902805 @default.
• W3090585870 hasConceptScore W3090585870C2779727006 @default.
• W3090585870 hasConceptScore W3090585870C2781274730 @default.
• W3090585870 hasConceptScore W3090585870C502942594 @default.
• W3090585870 hasConceptScore W3090585870C553184892 @default.
• W3090585870 hasConceptScore W3090585870C71924100 @default.
• W3090585870 hasConceptScore W3090585870C8891405 @default.
• W3090585870 hasLocation W30905858701 @default.
• W3090585870 hasOpenAccess W3090585870 @default.
• W3090585870 hasPrimaryLocation W30905858701 @default.
• W3090585870 hasRelatedWork W14742581 @default.
• W3090585870 hasRelatedWork W158596 @default.
• W3090585870 hasRelatedWork W19818330 @default.
• W3090585870 hasRelatedWork W20203410 @default.
• W3090585870 hasRelatedWork W20641688 @default.
• W3090585870 hasRelatedWork W2482010 @default.
• W3090585870 hasRelatedWork W2744283 @default.
• W3090585870 hasRelatedWork W2885605 @default.
• W3090585870 hasRelatedWork W4313372 @default.
• W3090585870 hasRelatedWork W6417289 @default.
• W3090585870 isParatext "false" @default.
• W3090585870 isRetracted "false" @default.
• W3090585870 magId "3090585870" @default.

• next