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- W3090606514 endingPage "664" @default.
- W3090606514 startingPage "645" @default.
- W3090606514 abstract "Tumor-associated macrophages (TAM) constitute up to 50–80% of stromal cells in breast cancer (BC), and are correlated with poor prognosis. As epidermal growth factor receptor (EGFR) is overexpressed in 60–80% of patients with triple negative breast cancer (TNBC), photoimmunotherapy (PIT) with cetuximab-targeted gold nanorods (CTX-AuNR) is an attractive therapeutic strategy for TNBC. The 3D cell culture model can mimic drug resistance conferred by the tumor microenvironment and its 3D organization; therefore, TAM and non-TAM embedded TNBC spheroids were constructed to evaluate the therapeutic efficacy of CTX-AuNR plus near infrared (NIR) irradiation. Cytotoxicity, reactive oxygen species (ROS) generation, and protein expression were compared in TNBC (± TAM) spheroids. The IC50 values of doxorubicin (DOX) in TAM-embedded TNBC spheroids were significantly higher than those in TNBC spheroids, demonstrating drug resistance, which could be explained by activation of IL-10/IL-10 receptor/STAT3/Bcl-2 signaling. However, 3D in vitro and in vivo results demonstrated that the efficacy of CTX-AuNR plus NIR irradiation was not significantly different in (± TAM) embedded TNBC cells. By enhancing ROS generation, CTX-AuNR plus NIR irradiation reprogrammed TAM polarization to the M1 anti-tumor phenotype, as indicated by macrophage mannose receptor (MMR) downregulation. Thus, CTX-AuNR plus NIR can serve as a potent PIT strategy for treating EGFR-overexpressing TNBC cells." @default.
- W3090606514 created "2020-10-08" @default.
- W3090606514 creator A5005324323 @default.
- W3090606514 creator A5008035486 @default.
- W3090606514 creator A5017417273 @default.
- W3090606514 creator A5022659794 @default.
- W3090606514 creator A5028506969 @default.
- W3090606514 creator A5037056963 @default.
- W3090606514 creator A5043260085 @default.
- W3090606514 creator A5083751923 @default.
- W3090606514 date "2021-01-01" @default.
- W3090606514 modified "2023-10-17" @default.
- W3090606514 title "Photoimmunotherapy with cetuximab-conjugated gold nanorods reduces drug resistance in triple negative breast cancer spheroids with enhanced infiltration of tumor-associated macrophages" @default.
- W3090606514 cites W1963717723 @default.
- W3090606514 cites W1968971179 @default.
- W3090606514 cites W1981825595 @default.
- W3090606514 cites W1983692618 @default.
- W3090606514 cites W1985420995 @default.
- W3090606514 cites W1993188287 @default.
- W3090606514 cites W2001717792 @default.
- W3090606514 cites W2004152105 @default.
- W3090606514 cites W2009597964 @default.
- W3090606514 cites W2028464008 @default.
- W3090606514 cites W2032007742 @default.
- W3090606514 cites W2044191242 @default.
- W3090606514 cites W2045810780 @default.
- W3090606514 cites W2056928766 @default.
- W3090606514 cites W2073916105 @default.
- W3090606514 cites W2074772243 @default.
- W3090606514 cites W2077731584 @default.
- W3090606514 cites W2080501134 @default.
- W3090606514 cites W2104174252 @default.
- W3090606514 cites W2111625999 @default.
- W3090606514 cites W2132265884 @default.
- W3090606514 cites W2141168419 @default.
- W3090606514 cites W2149121231 @default.
- W3090606514 cites W2153769134 @default.
- W3090606514 cites W2153917851 @default.
- W3090606514 cites W2157962067 @default.
- W3090606514 cites W2235739319 @default.
- W3090606514 cites W2236643502 @default.
- W3090606514 cites W2268448293 @default.
- W3090606514 cites W2296859605 @default.
- W3090606514 cites W2302383556 @default.
- W3090606514 cites W2309280425 @default.
- W3090606514 cites W2321158401 @default.
- W3090606514 cites W2399959131 @default.
- W3090606514 cites W2402636472 @default.
- W3090606514 cites W2409041580 @default.
- W3090606514 cites W2416345136 @default.
- W3090606514 cites W2463788395 @default.
- W3090606514 cites W2464349841 @default.
- W3090606514 cites W2496355268 @default.
- W3090606514 cites W2528538594 @default.
- W3090606514 cites W2529727810 @default.
- W3090606514 cites W2533513686 @default.
- W3090606514 cites W2553948338 @default.
- W3090606514 cites W2585760223 @default.
- W3090606514 cites W2586534662 @default.
- W3090606514 cites W2591884782 @default.
- W3090606514 cites W2595179999 @default.
- W3090606514 cites W2611870423 @default.
- W3090606514 cites W2614058962 @default.
- W3090606514 cites W2626044396 @default.
- W3090606514 cites W2725777854 @default.
- W3090606514 cites W2735818385 @default.
- W3090606514 cites W2737012672 @default.
- W3090606514 cites W2742716572 @default.
- W3090606514 cites W2761791218 @default.
- W3090606514 cites W2766010926 @default.
- W3090606514 cites W2774359813 @default.
- W3090606514 cites W2790885564 @default.
- W3090606514 cites W2801461341 @default.
- W3090606514 cites W2884602597 @default.
- W3090606514 cites W2887585631 @default.
- W3090606514 cites W2887616445 @default.
- W3090606514 cites W2887727631 @default.
- W3090606514 cites W2888803545 @default.
- W3090606514 cites W2895949525 @default.
- W3090606514 cites W2898416763 @default.
- W3090606514 cites W2900535246 @default.
- W3090606514 cites W2902757945 @default.
- W3090606514 cites W2903175024 @default.
- W3090606514 cites W2907900225 @default.
- W3090606514 cites W2908024650 @default.
- W3090606514 cites W2910968383 @default.
- W3090606514 cites W2911290679 @default.
- W3090606514 cites W2912531775 @default.
- W3090606514 cites W2916860038 @default.
- W3090606514 cites W2921579381 @default.
- W3090606514 cites W2921727504 @default.
- W3090606514 cites W2931547116 @default.
- W3090606514 cites W2936989468 @default.
- W3090606514 cites W2946898593 @default.
- W3090606514 cites W2949356422 @default.
- W3090606514 cites W2950002009 @default.
- W3090606514 cites W2953562073 @default.
- W3090606514 cites W2960605141 @default.