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- W3090625353 abstract "Abstract Considerable progress has been made in the development and understanding of immunotherapy, notably with the emergence of novel chimeric antigen receptor T cells (CAR‐T) which changed the perception of personalized therapy. However, cell‐based immunotherapy not only lacks therapeutic efficiency in various solid cancers but also raises concerns related to important side effects. The convergence of immunotherapy and nanomedicine is timely as nanoparticles can now be easily conjugated to various antibodies and peptides enabling outstanding abilities to target specific cell populations in vivo. Here, the state of the art of immunonanotherapy that activates the immune system in vivo, by acting either as vaccines or as tumor microenvironment (TME) activators is described. Then, the development of ex vivo immune‐cell surface labeling strategies is discussed to exploit immune cells as trojan horses and thereby improving the delivery of the therapeutics in the TME. Such a strategy is likely to considerably amplify the efficacy of immunotherapy." @default.
- W3090625353 created "2020-10-08" @default.
- W3090625353 creator A5005624697 @default.
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- W3090625353 creator A5032752413 @default.
- W3090625353 creator A5044903892 @default.
- W3090625353 creator A5082921719 @default.
- W3090625353 creator A5087243761 @default.
- W3090625353 date "2020-09-30" @default.
- W3090625353 modified "2023-10-06" @default.
- W3090625353 title "Leveraging Immunotherapy with Nanomedicine" @default.
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