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• W3090626812 abstract "HTLV-1 and HTLV-2 are endemic to Brazil, and they have different effects in HIV/AIDS disease progression. HIV/HTLV-1 has been described as accelerating the progression to AIDS and death, while HIV/HTLV-2 slows the progression to AIDS. Provirus mutations of HTLV-1 were implicated in severe leukemia development and in problems in the diagnosis of HTLV-1; in contrast, provirus mutations of HTLV-2 had not been confirmed and associated with problems in HTLV-2 diagnosis or disease outcome. Nevertheless, data obtained here allowed us to recognize and understand the false-negative results in serologic and molecular tests applied for HTLV-1 and HTLV-2 diagnosis. Defective proviruses, as well as synonymous and nonsynonymous mutations, were associated with the diagnosis deficiencies. Additionally, since HIV-1 and HTLV-1 infect the same cells (CD4 positive), the production of HIV-1 pseudotypes with HTLV-1 envelope glycoprotein during HIV/HTLV-1 coinfection cannot be excluded. Defective provirus of HTLV-2 and Tax2c is speculated to influence progression to AIDS." @default.
• W3090626812 created "2020-10-08" @default.
• W3090626812 creator A5006197803 @default.
• W3090626812 creator A5006472295 @default.
• W3090626812 date "2020-10-28" @default.
• W3090626812 modified "2023-10-18" @default.
• W3090626812 title "Provirus Mutations of Human T-Lymphotropic Virus 1 and 2 (HTLV-1 and HTLV-2) in HIV-1-Coinfected Individuals" @default.
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• W3090626812 doi "https://doi.org/10.1128/msphere.00923-20" @default.
• W3090626812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7529439" @default.
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• W3090626812 hasPublicationYear "2020" @default.
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