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• W3090647798 abstract "Abstract Background No available meta-analysis was printed to systematically introduce the MPNST clinic outcome and risk factors based on largely pooled data. This systematic review and meta-analysis aimed to investigate 5-year OS rate, 5-year EFS rate, and LR rate for MPNST, and to assess potential risk factors for prognosis. Methods Electronic articles published between January 1, 1966 and February 29, 2020 were searched and critically evaluated. The authors independently reviewed the abstracts and extracted data for 5-year OS rate, 5-year EFS rate, LR rate, and potential risk factors for prognosis. Results Twenty-eight literatures were finally included for meta-analysis. The pooled 5-year OS rate, 5-year EFS rate, and LR rate were 49%, 37%, and 38%, respectively. The significant prognostic factors for survival were NF1 status, tumor size, depth, location, malignant grade, margin status, chemotherapy, and radiotherapy. Age and sex were not associated with survival. Conclusion Survival and local recurrence of MPNST are poor. Worse prognosis is mainly associated with NF 1 , large size, deep to fascia, high grade, metastases, and location (trunk and head and neck). Complete resection with adequate surgical margins is the mainstay protective factor of MPNST patients, following necessary adjuvant therapies." @default.
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• W3090647798 date "2020-09-30" @default.
• W3090647798 modified "2023-10-18" @default.
• W3090647798 title "Prognosis and risk factors for malignant peripheral nerve sheath tumor: a systematic review and meta-analysis" @default.
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• W3090647798 doi "https://doi.org/10.1186/s12957-020-02036-x" @default.
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