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- W3090677385 abstract "Cancer is the second major cause of deaths next to noncommunicable diseases worldwide. The major treatment regimens followed to counter this disease include surgical resection, radiation therapy, and chemotherapy. These treatment regimens can be employed individually or in combinations. The heterogeneity in gastrointestinal (GI) cancers and development of resistance to chemotherapeutics agents and the secondary complication due to their toxic activity in normal cells lead to the research for discovery of novel therapeutics. With increasing knowledge of the aberrant signaling pathways in cancers, the novel approach to avoid the toxic effect of the chemotherapeutic drugs in normal cells was to look for targeted therapeutics. Targeted therapies include the use of either monoclonal antibodies against receptors or extracellular molecules present on cancer cells or using inhibitor molecules that target aberrant pathways in cancers. This chapter mostly focusses on discussing the role of protein kinase inhibitors a class of small molecule inhibitors in cancers with their functional significance and limitations." @default.
- W3090677385 created "2020-10-08" @default.
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- W3090677385 date "2020-01-01" @default.
- W3090677385 modified "2023-09-24" @default.
- W3090677385 title "Small Molecule-Targeted Therapies for GI Cancers: Success and Failures" @default.
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- W3090677385 doi "https://doi.org/10.1007/978-981-15-5471-1_4" @default.
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