Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090681129> ?p ?o ?g. }
- W3090681129 endingPage "584" @default.
- W3090681129 startingPage "575" @default.
- W3090681129 abstract "The transport of transepithelial Cl- and HCO3- is crucial for the function of the intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key chloride-bicarbonate exchanger protein in the intestinal epithelial luminal membrane, participates in the electroneutral NaCl absorption of intestine, together with Na+/H+ exchangers. Increasing recent evidence supports the essential role of decreased DRA function or expression in infectious diarrhea and inflammatory bowel disease (IBD).In this review, we give an overview of the current knowledge of Slc26a3, including its cloning and expression, function, roles in infectious diarrhea and IBD, and mechanisms of actions. A better understanding of the physiological and pathophysiological relevance of Slc26a3 in infectious diarrhea and IBD may reveal novel targets for future therapy.Understanding the physiological function, regulatory interactions, and the potential mechanisms of Slc26a3 in the pathophysiology of infectious diarrhea and IBD will define novel therapeutic approaches in future." @default.
- W3090681129 created "2020-10-08" @default.
- W3090681129 creator A5049546733 @default.
- W3090681129 date "2020-09-29" @default.
- W3090681129 modified "2023-10-10" @default.
- W3090681129 title "Slc26a3 (DRA) in the Gut: Expression, Function, Regulation, Role in Infectious Diarrhea and Inflammatory Bowel Disease" @default.
- W3090681129 cites W1550914708 @default.
- W3090681129 cites W1552056604 @default.
- W3090681129 cites W1821981622 @default.
- W3090681129 cites W1858782402 @default.
- W3090681129 cites W1969950838 @default.
- W3090681129 cites W1970477951 @default.
- W3090681129 cites W1980340049 @default.
- W3090681129 cites W1987141789 @default.
- W3090681129 cites W1989738331 @default.
- W3090681129 cites W1991438124 @default.
- W3090681129 cites W1991901136 @default.
- W3090681129 cites W1993790622 @default.
- W3090681129 cites W1994764127 @default.
- W3090681129 cites W1996646253 @default.
- W3090681129 cites W1996971261 @default.
- W3090681129 cites W2001258594 @default.
- W3090681129 cites W2001849494 @default.
- W3090681129 cites W2006800180 @default.
- W3090681129 cites W2008979188 @default.
- W3090681129 cites W2009086426 @default.
- W3090681129 cites W2016045507 @default.
- W3090681129 cites W2016547751 @default.
- W3090681129 cites W2021319837 @default.
- W3090681129 cites W2021922218 @default.
- W3090681129 cites W2022687523 @default.
- W3090681129 cites W2023471002 @default.
- W3090681129 cites W2026050056 @default.
- W3090681129 cites W2030364983 @default.
- W3090681129 cites W2033417601 @default.
- W3090681129 cites W2036877656 @default.
- W3090681129 cites W2039172663 @default.
- W3090681129 cites W2042729575 @default.
- W3090681129 cites W2045737849 @default.
- W3090681129 cites W2047638725 @default.
- W3090681129 cites W2050271023 @default.
- W3090681129 cites W2051318454 @default.
- W3090681129 cites W2052036406 @default.
- W3090681129 cites W2056745941 @default.
- W3090681129 cites W2058260460 @default.
- W3090681129 cites W2065357470 @default.
- W3090681129 cites W2067320696 @default.
- W3090681129 cites W2068786923 @default.
- W3090681129 cites W2071240489 @default.
- W3090681129 cites W2071854487 @default.
- W3090681129 cites W2075327064 @default.
- W3090681129 cites W2077049096 @default.
- W3090681129 cites W2078875288 @default.
- W3090681129 cites W2081625849 @default.
- W3090681129 cites W2084716544 @default.
- W3090681129 cites W2089225995 @default.
- W3090681129 cites W2091349763 @default.
- W3090681129 cites W2093590110 @default.
- W3090681129 cites W2095348084 @default.
- W3090681129 cites W2097306022 @default.
- W3090681129 cites W2100965631 @default.
- W3090681129 cites W2105471476 @default.
- W3090681129 cites W2112002571 @default.
- W3090681129 cites W2114781095 @default.
- W3090681129 cites W2115217458 @default.
- W3090681129 cites W2117712813 @default.
- W3090681129 cites W2118252780 @default.
- W3090681129 cites W2119575920 @default.
- W3090681129 cites W2122382513 @default.
- W3090681129 cites W2123314654 @default.
- W3090681129 cites W2124871358 @default.
- W3090681129 cites W2126371598 @default.
- W3090681129 cites W2128684716 @default.
- W3090681129 cites W2133002738 @default.
- W3090681129 cites W2134923459 @default.
- W3090681129 cites W2137207669 @default.
- W3090681129 cites W2139993911 @default.
- W3090681129 cites W2144924831 @default.
- W3090681129 cites W2152745352 @default.
- W3090681129 cites W2152751713 @default.
- W3090681129 cites W2153039235 @default.
- W3090681129 cites W2154960204 @default.
- W3090681129 cites W2158010031 @default.
- W3090681129 cites W2159137116 @default.
- W3090681129 cites W2159753899 @default.
- W3090681129 cites W2163374484 @default.
- W3090681129 cites W2166520529 @default.
- W3090681129 cites W2169048787 @default.
- W3090681129 cites W2169500993 @default.
- W3090681129 cites W2170238283 @default.
- W3090681129 cites W2172791683 @default.
- W3090681129 cites W2199817432 @default.
- W3090681129 cites W2219752963 @default.
- W3090681129 cites W2261798779 @default.
- W3090681129 cites W2519442386 @default.
- W3090681129 cites W2621256940 @default.
- W3090681129 cites W2747732793 @default.
- W3090681129 cites W2782117197 @default.